Critical pathways to success in CNS drug development - Cutler, Neal R. (Chichester, UK ; Hoboken, NJ : Wiley-Blackwell, 2010)
The impending crisis in CNS drug development -- Animal models and procedures for CNS disorders -- Pre-clinical antecedents to early human clinical trials -- Biomarkers and surrogate markers in drug development -- Neuroimaging and cognitive assessments in early drug development -- Bridging and CSF studies -- A case study from pre-clinical to early clinical trials.
Keywords: Neuropsychopharmacology; Drug development; Critical path analysis; Central nervous system -- Effect of drugs on -- Research -- Methodology; Central Nervous System Agents -- pharmacology; Clinical Trials as Topic -- methods; Drug Evaluation -- methods; Drug Evaluation, Preclinical -- methods