TY  - THES
TY  - BOOK
T1  - Chemical constituents of Agathis borneensis warb. (Damar Minyak) a potential antiplasmodial resource
A1  - Suzika Juiling.
LA  - English
YR  - 2017
UL  - http://discoverylib.upm.edu.my/discovery/Record/561906
AB  - ABSTRACT 
Agathis borneensis Warb. (Araucareaceae) is a traditional medicinal plant widely distributed in the Borneo Island. This plant is commonly used by the traditional healers to treat fever cause by malaria disease. However, bioactive components of A. borneensis that react with malaria parasite are unknown. The present study was to describe the chemical composition and medicinal properties of compounds from A. borneensis that associates to antimalarial. Chemical constituents of the leaves and stembark extracts of A. borneensis were analyzed by TLC and GC-MS. About 63 compounds, constituting five major classes of terpenes were identified; monoterpene hydrocarbons, oxygenated monoterpenes, sesquiterpene hydrocarbons, oxygenated sesquiterpenes and oxygenated diterpenes. Sesquiterpenes content was high in leaves (29.2%) and low in the stembark (10.4%). Oxygenated sesquiterpene group was present at high level in the stembark (11.4%), while both monoterpene (0.9%) and oxygenated monoterpenes (2.3%) were present in small amount. Oxygenated diterpenes (6.8%) was only found in the leaves. The principles of bioactive compounds found in this plant were β-caryophyllene, farnesol, cyclohexane, germacrene D, and δ-cadinene. In conclusion, A. borneensis has the potential for use as antiplasmodial agent with the present of β-caryophyllene and caryophyllene oxide in the leaf and stembark of the tree.

Key Words : Antiplasmodial activities, caryophyllene oxide, chemical constituents, GCMS, medicinal plant, sesquiterpenes, TLC, β-caryophyllene
CN  - FH 2017 1
ER  -