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Design and Analysis of Vaccine Studies

Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at t...

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Bibliographic Details
Main Authors: Halloran, M. Elizabeth. (Author, http://id.loc.gov/vocabulary/relators/aut), Longini, Jr., Ira M. (http://id.loc.gov/vocabulary/relators/aut), Struchiner, Claudio J. (http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2010.
Edition:1st ed. 2010.
Series:Statistics for Biology and Health,
Subjects:
Health informatics.
Epidemiology.
Infectious diseases.
Statistics .
Health Informatics.
Infectious Diseases.
Statistics for Life Sciences, Medicine, Health Sciences.
Online Access:https://doi.org/10.1007/978-0-387-68636-3
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Table of Contents:
  • and Examples
  • Overview of Vaccine Effects and Study Designs
  • Immunology and Early Phase Trials
  • Binomial and Stochastic Transmission Models
  • and Deterministic Models
  • Evaluating Protective Effects of Vaccination
  • Modes of Action and Time-Varying VE
  • Further Evaluation of Protective Effects
  • Vaccine Effects on Post-Infection Outcomes
  • Household-Based Studies
  • Analysis of Households in Communities
  • Analysis of Independent Households
  • Assessing Indirect, Total, and Overall Effects
  • Randomization and Baseline Transmission
  • Surrogates of Protection.

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