Neurochemical Aspects of Excitotoxicity

About 40% of central nervous system synapses use glutamate as the neurotransmitter. Over-stimulation of glutamate receptors produces neuronal injury or death by excitotoxicity, which is closely associated with neurochemical and neuropathological changes involved in acute neural trauma (stroke, spina...

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Hlavní autoři: Farooqui, Akhlaq A. (Autor, http://id.loc.gov/vocabulary/relators/aut), Ong, Wei-Yi. (http://id.loc.gov/vocabulary/relators/aut), Horrocks, Lloyd A. (http://id.loc.gov/vocabulary/relators/aut)
Korporativní autor: SpringerLink (Online service)
Médium: Elektronický zdroj E-kniha
Jazyk:English
Vydáno: New York, NY : Springer New York : Imprint: Springer, 2008.
Vydání:1st ed. 2008.
Témata:
On-line přístup:https://doi.org/10.1007/978-0-387-73023-3
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Obsah:
  • Glutamate and Aspartate in Brain
  • Excitatory Amino Acid Receptors in Brain
  • Multiplicity of Glutamate Receptors in Brain
  • Glutamate Transporters and Their Role in Brain
  • Excitatory Amino Acid Receptors and Their Association with Neural Membrane Glycerophospholipid Metabolism
  • Glutamate Receptors and Their Association with Other Neurochemical Parameters in Excitotoxicity
  • Possible Mechanisms of Neural Injury Caused by Glutamate and Its Receptors
  • Glutamate Receptors and Neurological Disorders
  • Endogenous Antioxidant Mechanisms and Glutamate Neurotoxicity
  • Glutamate Receptor Antagonists and the Treatment of Neurological Disorders
  • Future Perspectives: New Strategies for Antagonism of Excitotoxicity, Oxidative Stress and Neuroinflammation in Neurodegenerative Diseases.