TY  - GEN
TY  - GEN
T1  - Post-Translational Modifications in Health and Disease
T2  - Protein Reviews ;
A2  - Vidal, Cecilio J.
A2  - Vidal, Cecilio J.
LA  - English
PP  - New York, NY
PB  - Springer New York : Imprint: Springer
YR  - 2011
ED  - 1st ed. 2011.
UL  - http://discoverylib.upm.edu.my/discovery/Record/978-1-4419-6382-6
AB  - Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.
OP  - 490
CN  - QH345
SN  - 9781441963826
KW  - Biochemistry.
KW  - Medical biochemistry.
KW  - Cell biology.
KW  - Biochemistry, general.
KW  - Animal Biochemistry.
KW  - Medical Biochemistry.
KW  - Cell Biology.
ER  -