TY - GEN TY - GEN T1 - Alcohol and Cancer A2 - Zakhari, Samir. A2 - Zakhari, Samir. A2 - Vasiliou, Vasilis. A2 - Vasiliou, Vasilis. A2 - Guo, Q. Max. A2 - Guo, Q. Max. LA - English PP - New York, NY PB - Springer New York : Imprint: Springer YR - 2011 ED - 1st ed. 2011. UL - http://discoverylib.upm.edu.my/discovery/Record/978-1-4614-0040-0 AB - The World Health Organization has identified chronic alcohol consumption as one of the top ten risk factors for worldwide burden of disease. The International Agency for Research on Cancer has identified alcohol as carcinogenic to humans, including cancers of the upper aerodigestive tract, colon, liver and breast. Alcohol’s actions may be direct e.g. effects on retinoic acid and one-carbon metabolism, or indirect, through metabolites such as acetaldehyde and reactive oxygen species or through various signaling pathways that influence cell cycle and apoptosis that may contribute to carcinogenesis. This volume reviews the state of the art in alcohol-related cancer research in ten chapters. OP - 243 CN - RC261-271 SN - 9781461400400 KW - Cancer research. KW - Pharmacology. KW - Cancer Research. KW - Pharmacology/Toxicology. ER -