TY  - GEN
TY  - GEN
T1  - Patho-Epigenetics of Disease
A2  - Minarovits, Janos.
A2  - Minarovits, Janos.
A2  - Niller, Hans Helmut.
A2  - Niller, Hans Helmut.
LA  - English
PP  - New York, NY
PB  - Springer New York : Imprint: Springer
YR  - 2012
ED  - 1st ed. 2012.
UL  - http://discoverylib.upm.edu.my/discovery/Record/978-1-4614-3345-3
AB  - In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.
OP  - 466
CN  - QR46
SN  - 9781461433453
KW  - Medical microbiology.
KW  - Medicine.
KW  - Virology.
KW  - Infectious diseases.
KW  - Immunology.
KW  - Medical Microbiology.
KW  - Medicine/Public Health, general.
KW  - Infectious Diseases.
ER  -