TY  - GEN
TY  - GEN
T1  - Gadd45 Stress Sensor Genes
T2  - Advances in Experimental Medicine and Biology,
A2  - Liebermann, Dan A.
A2  - Liebermann, Dan A.
A2  - Hoffman, Barbara.
A2  - Hoffman, Barbara.
LA  - English
PP  - New York, NY
PB  - Springer New York : Imprint: Springer
YR  - 2013
ED  - 1st ed. 2013.
UL  - http://discoverylib.upm.edu.my/discovery/Record/978-1-4614-8289-5
AB  - Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  .
OP  - 134
CN  - RB155-155.8
SN  - 9781461482895
KW  - Medical genetics.
KW  - Biochemistry.
KW  - Human genetics.
KW  - Gene Function.
KW  - Biochemistry, general.
KW  - Human Genetics.
ER  -