Suicide Gene Therapy Methods and Reviews /
Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In t...
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| 団体著者: | |
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| その他の著者: | |
| フォーマット: | 電子媒体 eBook |
| 言語: | English |
| 出版事項: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2004.
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| 版: | 1st ed. 2004. |
| シリーズ: | Methods in Molecular Medicine,
90 |
| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1385/1592594298 |
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| LEADER | 04160nam a22004455i 4500 | ||
|---|---|---|---|
| 001 | 978-1-59259-429-0 | ||
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| 024 | 7 | |a 10.1385/1592594298 |2 doi | |
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| 245 | 1 | 0 | |a Suicide Gene Therapy |h [electronic resource] : |b Methods and Reviews / |c edited by Caroline J. Springer. |
| 250 | |a 1st ed. 2004. | ||
| 264 | 1 | |a Totowa, NJ : |b Humana Press : |b Imprint: Humana, |c 2004. | |
| 300 | |a XIV, 555 p. |b online resource. | ||
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| 490 | 1 | |a Methods in Molecular Medicine, |x 1543-1894 ; |v 90 | |
| 505 | 0 | |a to the Background, Principles, and State of the Art in Suicide Gene Therapy -- to Vectors for Suicide Gene Therapy -- Construction of VNP20009 -- Nonreplicating DNA Viral Vectors for Suicide Gene Therapy -- Replication-Selective Oncolytic Adenoviruses -- Retroviral Vectors for Suicide Gene Therapy -- Nonviral Liposomes -- Peptide- and Polymer-Based Gene Delivery Vehicles -- Design of Prodrugs for Suicide Gene Therapy -- Cytochrome P450-Based Gene Therapies for Cancer -- Tumor Sensitization to Purine Analogs by E. coli PNP -- Enzyme-Prodrug Systems -- Enzyme-Prodrug Systems -- Methods to Improve Efficacy in Suicide Gene Therapy Approaches -- Extracellular ?-Glucuronidase for Gene-Directed Enzyme-Prodrug Therapy -- Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis -- Combination Suicide Gene Therapy -- Immune Response to Suicide Gene Therapy -- Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus -- Radiation-Activated Antitumor Vectors -- In Vitro and In Vivo Models for Evaluation of GDEPT -- Suicide Gene Therapy in Liver Tumors -- Clinical Trials With GDEPT -- The Nitroreductase/CB1954 Enzyme-Prodrug System -- Side Effects of Suicide Gene Therapy -- Antibody-Directed Enzyme-Prodrug Therapy -- Bioreductive Prodrugs for Cancer Therapy. | |
| 520 | |a Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications. | ||
| 650 | 0 | |a Oncology . | |
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