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Protein Tyrosine Kinases From Inhibitors to Useful Drugs /

Protein kinases function as components of signal transduction pathways, playing a central role in the control of cell growth, metabolism, differentiation, and apoptosis. The development of selective protein tyrosine kinase (PTK) inhibitors that can block or modulate diseases, such as cancer, with ab...

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Dettagli Bibliografici
Ente Autore: SpringerLink (Online service)
Altri autori: Fabbro, Doriano. (Redattore, http://id.loc.gov/vocabulary/relators/edt), McCormick, Frank. (Redattore, http://id.loc.gov/vocabulary/relators/edt)
Natura: Elettronico eBook
Lingua:English
Pubblicazione: Totowa, NJ : Humana Press : Imprint: Humana, 2006.
Edizione:1st ed. 2006.
Serie:Cancer Drug Discovery and Development,
Soggetti:
Biochemistry.
Biochemistry, general.
Accesso online:https://doi.org/10.1385/1592599621
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Sommario:
  • Protein Tyrosine Kinases as Targets for Cancer and Other Indications
  • Inhibitors of Signaling Interfaces
  • PI3-Kinase Inhibition
  • Src as a Target for Pharmaceutical Intervention
  • Activated FLT3 Receptor Tyrosine Kinase as a Therapeutic Target In Leukemia
  • JAK Kinases in Leukemias, Lymphomas, and Multiple Myeloma
  • Glivec® (Gleevec®, Imatinib, STI571)
  • Platelet-Derived Growth Factor
  • Structural Biology of Protein Tyrosine Kinases
  • Testing of Signal Transduction Inhibitors in Animal Models of Cancer
  • Phosphoproteomics in Drug Discovery and Development.

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