TY  - GEN
TY  - GEN
T1  - Free-Radical-Induced DNA Damage and Its Repair A Chemical Perspective
A1  - Sonntag, Clemens.
LA  - English
PP  - Berlin, Heidelberg
PB  - Springer Berlin Heidelberg : Imprint: Springer
YR  - 2006
ED  - 1st ed. 2006.
UL  - http://discoverylib.upm.edu.my/discovery/Record/978-3-540-30592-7
AB  - Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
OP  - 523
CN  - QH345
SN  - 9783540305927
KW  - Biochemistry.
KW  - Cell biology.
KW  - Life sciences.
KW  - Molecular biology.
KW  - Oncology  .
KW  - Organic chemistry.
KW  - Biochemistry, general.
KW  - Cell Biology.
KW  - Life Sciences, general.
KW  - Molecular Medicine.
KW  - Oncology.
KW  - Organic Chemistry.
ER  -