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Phosphoinositides I: Enzymes of Synthesis and Degradation

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegene...

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Dettagli Bibliografici
Ente Autore: SpringerLink (Online service)
Altri autori: Balla, Tamas. (Redattore, http://id.loc.gov/vocabulary/relators/edt), Wymann, Matthias. (Redattore, http://id.loc.gov/vocabulary/relators/edt), York, John D. (Redattore, http://id.loc.gov/vocabulary/relators/edt)
Natura: Elettronico eBook
Lingua:English
Pubblicazione: Dordrecht : Springer Netherlands : Imprint: Springer, 2012.
Edizione:1st ed. 2012.
Serie:Subcellular Biochemistry, 58
Soggetti:
Medicine.
Neurosciences.
Human genetics.
Molecular biology.
Medical genetics.
Neurochemistry.
Biomedicine, general.
Human Genetics.
Molecular Medicine.
Gene Function.
Accesso online:https://doi.org/10.1007/978-94-007-3012-0
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Sommario:
  • 1. The Phosphatidylinositol 4-kinases: Don’t Call it a Comeback
  • 2. PIP kinases from the cell membrane to the nucleus
  • 3. The Phospholipase C Isozymes and Their Regulation.- 4. Phosphoinositide 3-Kinases – A Historical Perspective
  • 5. PI 3-kinases – drug targets in inflammation and cancer
  • 6. Phosphoinositide 3-kinases in health and disease
  • 7. Phosphoinositide phosphatases: just as important as the kinases
  • 8. The PTEN and myobubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.

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