Mutant p53 and MDM2 in Cancer
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning...
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| 企业作者: | |
|---|---|
| 其他作者: | , |
| 格式: | 电子 电子书 |
| 语言: | English |
| 出版: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2014.
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| 版: | 1st ed. 2014. |
| 丛编: | Subcellular Biochemistry,
85 |
| 主题: | |
| 在线阅读: | https://doi.org/10.1007/978-94-017-9211-0 |
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书本目录:
- p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer
- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis
- p53 mutation in the genesis of metastasis
- Structural studies on mechanisms to activate mutant p53
- Mutant p53 and the response to chemotherapy and radiation
- The p53-MDM2 loop: a critical juncture of stress response
- Mechanisms of mutant p53 stabilization in cancer
- Crosstalk between Mdm2, p53 and HIF-1α: distinct responses to oxygen stress and implications for tumour hypoxia
- MDM2 overexpression, activation of signaling networks, and cell proliferation
- p53-independent effects of MDM2
- Splice variants of MDM2 in oncogenesis
- MDM2 and MDMX involvement in human cancer
- Targeting the p53-MDM2- MDMX loop for cancer therapy
- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)
- The role of tumor suppressor p53 in the antioxidant defense and metabolism
- Lung cancer stem cells, p53 mutations and MDM2.