Imagem da capa

Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7

Researchers are exploring better treatments in cancer. The identification of active plant chemicals and the study of their biological activities are extensively being pursued. The five objectives in this study were to determine the antioxidant activity of rice bran extracts, to isolate oryzanol from...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Autor principal: Md Akim, Abdah
Formato: Tese
Idioma:English
Publicado em: 2004
Acesso em linha:http://ethesis.upm.edu.my/id/eprint/2301/1/FPSK%28P%29_2004_3F.pdf
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id oai:ethesis.upm.edu.my:2301
record_format eprints
spelling oai:ethesis.upm.edu.my:2301 http://ethesis.upm.edu.my/id/eprint/2301/ Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7 Md Akim, Abdah Researchers are exploring better treatments in cancer. The identification of active plant chemicals and the study of their biological activities are extensively being pursued. The five objectives in this study were to determine the antioxidant activity of rice bran extracts, to isolate oryzanol from rice bran, to determine the cytotoxicity activity of oryzanol, stigmasterol and microminutinin, to investigate the morphological changes in MCF7 cells treated with oryzanol, stigmasterol and microminutinin and to study on the effect of these compounds on c-myc, c-fos and c-erbB2 gene expression. The antioxidant activities of various rice bran extracts were carried out to determine the best organic solvent extraction. In the Ferric Thiocyanate (FTC) and Thiobarbiturate (TBA) assays, chloroform extract (FTC; 92%, TBA; 82%) had the highest antioxidant activity followed by ethyl acetate (FTC;90%, TBA;79%) methanol (FTC;90%, TBA;79%) and hexane (FTC; 89%, TBA;77%) extracts. The antioxidant activities in the ~-carotene degradation assay gave similar findings. Comparison between the antioxidant activities 2004-10 Thesis NonPeerReviewed application/pdf en http://ethesis.upm.edu.my/id/eprint/2301/1/FPSK%28P%29_2004_3F.pdf Md Akim, Abdah (2004) Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7. PhD thesis, Universiti Putra Malaysia. (FPSK(P) 2004 3).
institution UPM eTHESES
collection UPM eTHESES
language English
description Researchers are exploring better treatments in cancer. The identification of active plant chemicals and the study of their biological activities are extensively being pursued. The five objectives in this study were to determine the antioxidant activity of rice bran extracts, to isolate oryzanol from rice bran, to determine the cytotoxicity activity of oryzanol, stigmasterol and microminutinin, to investigate the morphological changes in MCF7 cells treated with oryzanol, stigmasterol and microminutinin and to study on the effect of these compounds on c-myc, c-fos and c-erbB2 gene expression. The antioxidant activities of various rice bran extracts were carried out to determine the best organic solvent extraction. In the Ferric Thiocyanate (FTC) and Thiobarbiturate (TBA) assays, chloroform extract (FTC; 92%, TBA; 82%) had the highest antioxidant activity followed by ethyl acetate (FTC;90%, TBA;79%) methanol (FTC;90%, TBA;79%) and hexane (FTC; 89%, TBA;77%) extracts. The antioxidant activities in the ~-carotene degradation assay gave similar findings. Comparison between the antioxidant activities
format Thesis
author Md Akim, Abdah
spellingShingle Md Akim, Abdah
Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
author_facet Md Akim, Abdah
author_sort Md Akim, Abdah
title Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
title_short Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
title_full Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
title_fullStr Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
title_full_unstemmed Biological Activities of Oryzanol, Stigmasterol and Microminutinin on Human Breast Cancer Cell-Line, MCF7
title_sort biological activities of oryzanol, stigmasterol and microminutinin on human breast cancer cell-line, mcf7
publishDate 2004
url http://ethesis.upm.edu.my/id/eprint/2301/1/FPSK%28P%29_2004_3F.pdf
_version_ 1819310242535571456
score 13.4562235

Registros relacionados