TY  - GEN
T1  - Effect of Bacillus thuringiensis based-products on rats
A1  - Mohd Najib Ahmad
LA  - English
YR  - 2020
UL  - http://discoverylib.upm.edu.my/discovery/Record/oai:http:--agris.upm.edu.my:0-17177
AB  - Registration of pesticides with the National Pesticide Board must undergo laboratory testing for short-term and long-term health effects. Laboratory animals such as rats are purposely fed with high doses of the pesticide to cause toxic effects. The objectives of this study are to investigate the effect of Bacillus thuringiensis-based Bafog-1 (S) and Ecobac-1 (EC) against Sprague Dawley rats, to assess the toxicity of these Bt products. The acute oral and acute dermal toxicity studies were conducted according to OECD (Organisation for Economic Co-operation and Development) Guideline for Testing of Chemicals 425 (2001) and 402 (1987), respectively. The oral LD50 of Ecobac-1 (EC) and Bafog-1 (S) on female rats is more than 5000 mg kg-1, when administered orally with dose of 175 mg kg-1, respectively. Correspondingly, the LD50 for dermal administration of both Bt products is more than 2000 mg kg-1 for both male and female rats. There was no toxic symptom observed during the two weeks observation period in male and female rats. Post-mortem of the dermally treated animals at the end of the experiment did not show changes or adverse effect in the rats’ internal organs, indicating these two products are non-toxic to rats. Bt as an environmental-friendly microbial insecticide is generally not toxic to human, domestic animals and vertebrates.
KW  - Bacillus thuringiensis
KW  - Bacterial insecticides
KW  - Biological control agents
KW  - Biological control
KW  - Insecticides
KW  - Animal models
KW  - Fermentation
KW  - Laboratory animals
KW  - Acute toxicity
KW  - Oral administration
KW  - Mortality
KW  - Toxicology
KW  - Toxicity
ER  -