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Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans

Candida albicans is a fungus that is included in the normal microbiota of humans. In general, C. albicans remains a lifelong commensal microorganism. This fungus has a hazardous impact. C. albicans can cause infection and is fatal. The spread of this fungus is one of the factors caused by antibiotic...

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Autors principals:	Nurwijayanto, A., Siregar, K. A. A. K., Hamzah, H., Suffiana, Y., Yudhawan, I.
Format:	Journal Contribution
Idioma:	English
Publicat:	2024
Matèries:	Leaf extracts Candida albicans Antibacterial agents Medicinal plants Experiments Sampling Equipment testing Statistical methods Medicinal properties Aftereffects (of residues)
Accés en línia:	http://agris.upm.edu.my:8080/dspace/handle/0/24488
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spelling	oai:http:--agris.upm.edu.my:0-24488Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicansNurwijayanto, A.Siregar, K. A. A. K.Hamzah, H.Suffiana, Y.Yudhawan, I.Leaf extractsCandida albicansAntibacterial agentsMedicinal plantsExperimentsSamplingEquipment testingStatistical methodsMedicinal propertiesAftereffects (of residues)Candida albicans is a fungus that is included in the normal microbiota of humans. In general, C. albicans remains a lifelong commensal microorganism. This fungus has a hazardous impact. C. albicans can cause infection and is fatal. The spread of this fungus is one of the factors caused by antibiotic resistance, which causes C. albicans to be resistant and form strong colonies (biofilms) to survive. Natural ingredients for treatment is an alternative that is often used by the community because their use is effortless and practical. One of the plants is the leaves of Begonia multangula Blume. This plant is known to have potent antifungal activity, but its antibiofilm activity against C. albicans has not yet been reported in-depth about its antibiofilm. The discovery of new antibiofilm against C. albicans biofilms is a way to prevent the effects of infections caused by these biofilms. This research is a form of dedication to the effectiveness of Begonia multangula Blume leaf extract in inhibiting and eradicating C. albicans biofilm formation. Planktonic testing, inhibition, and biofilm eradication activity were carried out using the microtiter broth method. Antibiofilm activity of begonia leaves on C. albicans was measured by calculating the minimum concentration of biofilm inhibitor (MBIC₅₀). Data were analyzed using the Statistical Package for the Social Sciences (SPSS) with a 95% confidence level. The begonia leaves showed inhibitory activity against the tested C. albicans biofilm formation. Begonia multangula Blume leaf extract 1% gave C. albicans antibacterial activity of 75±0.01% and mid-phase antibiofilm activity of 65.21±0.01% and maturation phase of 50.11±0.01. The results also provided evidence that the ethanolic extract of C. albicans can degrade (eradication) the formation of C. albicans biofilms. Therefore, the ethanol extract of begonia leaves can be developed as a new antibiofilm agent against C. albicans.2024-06-24T04:24:25Z2024-06-24T04:24:25Z2022Journal ContributionArticleNon-RefereedMY2024050788Food Research (Malaysia), 6 (1), p. 260-2682550-2166http://agris.upm.edu.my:8080/dspace/handle/0/24488enhttps://www.myfoodresearch.com/uploads/8/4/8/5/84855864/_33__fr-2021-560_hamzah.pdfIndonesiahttp://www.oceandocs.org/license
institution	AGRIS
collection	AGRIS
language	English
topic	Leaf extracts Candida albicans Antibacterial agents Medicinal plants Experiments Sampling Equipment testing Statistical methods Medicinal properties Aftereffects (of residues)
spellingShingle	Leaf extracts Candida albicans Antibacterial agents Medicinal plants Experiments Sampling Equipment testing Statistical methods Medicinal properties Aftereffects (of residues) Nurwijayanto, A. Siregar, K. A. A. K. Hamzah, H. Suffiana, Y. Yudhawan, I. Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
description	Candida albicans is a fungus that is included in the normal microbiota of humans. In general, C. albicans remains a lifelong commensal microorganism. This fungus has a hazardous impact. C. albicans can cause infection and is fatal. The spread of this fungus is one of the factors caused by antibiotic resistance, which causes C. albicans to be resistant and form strong colonies (biofilms) to survive. Natural ingredients for treatment is an alternative that is often used by the community because their use is effortless and practical. One of the plants is the leaves of Begonia multangula Blume. This plant is known to have potent antifungal activity, but its antibiofilm activity against C. albicans has not yet been reported in-depth about its antibiofilm. The discovery of new antibiofilm against C. albicans biofilms is a way to prevent the effects of infections caused by these biofilms. This research is a form of dedication to the effectiveness of Begonia multangula Blume leaf extract in inhibiting and eradicating C. albicans biofilm formation. Planktonic testing, inhibition, and biofilm eradication activity were carried out using the microtiter broth method. Antibiofilm activity of begonia leaves on C. albicans was measured by calculating the minimum concentration of biofilm inhibitor (MBIC₅₀). Data were analyzed using the Statistical Package for the Social Sciences (SPSS) with a 95% confidence level. The begonia leaves showed inhibitory activity against the tested C. albicans biofilm formation. Begonia multangula Blume leaf extract 1% gave C. albicans antibacterial activity of 75±0.01% and mid-phase antibiofilm activity of 65.21±0.01% and maturation phase of 50.11±0.01. The results also provided evidence that the ethanolic extract of C. albicans can degrade (eradication) the formation of C. albicans biofilms. Therefore, the ethanol extract of begonia leaves can be developed as a new antibiofilm agent against C. albicans.
format	Journal Contribution
author	Nurwijayanto, A. Siregar, K. A. A. K. Hamzah, H. Suffiana, Y. Yudhawan, I.
author_facet	Nurwijayanto, A. Siregar, K. A. A. K. Hamzah, H. Suffiana, Y. Yudhawan, I.
author_sort	Nurwijayanto, A.
title	Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
title_short	Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
title_full	Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
title_fullStr	Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
title_full_unstemmed	Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans
title_sort	antibacterial and antibiofilm activity of begonia multangula blume. leaf extract against candida albicans
publishDate	2024
url	http://agris.upm.edu.my:8080/dspace/handle/0/24488
_version_	1819285869914226688
score	13.4562235

Antibacterial and antibiofilm activity of Begonia multangula Blume. leaf extract against Candida albicans

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