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TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in T...

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Main Authors: Liu, Gang, Haw, Tatt Jhong, Starkey, Malcolm R., Philp, Ashleigh M., Pavlidis, Stelios, Nalkurthi, Christina, Nair, Prema M., Gomez, Henry M., Hanish, Irwan, Hsu, Alan CY., Hortle, Elinor, Pickles, Sophie, Rojas-Quintero, Joselyn, Estepar, Raul San Jose, Marshall, Jacqueline E., Kim, Richard Y., Collison, Adam M., Mattes, Joerg, Idrees, Sobia, Faiz, Alen, Hansbro, Nicole G., Fukui, Ryutaro, Murakami, Yusuke, Cheng, Hong Sheng, Tan, Nguan Soon, Chotirmall, Sanjay H., Horvat, Jay C., Foster, Paul S., Oliver, Brian GG., Polverino, Francesca, Ieni, Antonio, Monaco, Francesco, Caramori, Gaetano, Sohal, Sukhwinder S., Bracke, Ken R., Wark, Peter A., Adcock, Ian M., Miyake, Kensuke, Sin, Don D., Hansbro, Philip M.
Format: Article
Izdano: Nature Publishing 2023
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