TY  - THES
T1  - Protective Effect Of Phenorbarbitone And Griseofulvin Againt Signal Grass (Brachiaria Decumbens)Toxiciti In Sheep
A1  - Ab. Hamid, Hasiah
LA  - English
LA  - English
YR  - 2001
UL  - http://discoverylib.upm.edu.my/discovery/Record/oai:psasir.upm.edu.my:11224
AB  - The protective effect of phenobarbitone and griseofulvin against signal grass (B.
decumbens) toxicity were studied in fifty-three Wiltshire x Malin (Indigenous
Malaysian) male sheep. Twenty-six animals were used in phenobarbitone experiment
and twenty-seven animals were used in griseofulvin experiment. Grazing on signal
grass significantly decreased the concentration of cytochrome P-4S0 and the activity
of drug metabolizing enzyme, viz. aminopyrine-N-demethylase, aniline-4-
hydroxylase, UDP-glucuronyltransferase and glutathione-S-transferase in liver and
kidney of sheep. The concentration of cytochrome P-4S0 was determined in
microsomal fraction according to the method of Omura and Sato (1964a) as described
by Mazel (1971). The activities of aminopyrine-N-demethylase and aniline-4-
hydroxylase were determined using Mazel, 1971 method by estimating the
ER  -