TY  - JOUR
T1  - An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones
A1  - Tamil Segaran, Raaginie
LA  - English
PB  - Elsevier
YR  - 2024
UL  - http://discoverylib.upm.edu.my/discovery/Record/oai:psasir.upm.edu.my:113457
AB  - The synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones with 15.1–36.9% yield was achieved via aldol condensation of 2,4,6-trihydroxy-3-prenylacetophenone (tHPA) or 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) and 2-hydroxybenzaldehyde derivatives in the presence of lithium bis(trimethylsilyl)amide (LiHMDS) as deprotonating agent. This study is one of the first to report on the synthesis of xanthenones using strong non-nucleophilic base catalyst, and the described synthesis not only achieved a compound with a natural product skeleton but also formed in a simple and environmentally friendly specificity.
ER  -