Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis

OBJECTIVES: The growth inhibiting potential of andrographolide was evaluated in three acute promyelocytic leukaemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2). METHODS: In elucidating the mechanisms of growth inhibition, a special emphasis was placed on assess...

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Bibliographic Details
Main Authors: Manikam, Shiamala Devi, Stanslas, Johnson
Format: Article
Published: John Wiley & Sons 2009
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