Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
The aqueous extract of Ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. The results of the present study showed that intraperitoneal administration of the F. deltoid...
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2008
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oai:psasir.upm.edu.my:14612 http://psasir.upm.edu.my/id/eprint/14612/ Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Sulaiman, Mohd Roslan Hussain, Mohd. Khairi Zakaria, Zainul Amiruddin Somchit, M.N. Moin, Saidi Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad The aqueous extract of Ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. The results of the present study showed that intraperitoneal administration of the F. deltoidea leaves aqueous extract at the dose of 1, 50 and 100 mg/kg, 30 min prior to pain induction produced significant dose-dependent antinociceptive effect in all the models used, which indicating the presence of both central and peripherally mediated activities. Furthermore, the antinociceptive effect of the extract in the formalin and hot plate test was reversed by the non-selective opioid receptor antagonist naloxone suggesting that the endogenous opioid system is involved in its analgesic mechanism of action. Thus, the present results demonstrated that F. deltoidea leaves aqueous extract contains pharmacologically active constituents which possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions. Elsevier 2008-12 Article PeerReviewed Sulaiman, Mohd Roslan and Hussain, Mohd. Khairi and Zakaria, Zainul Amiruddin and Somchit, M.N. and Moin, Saidi and Tengku Mohamad, Tengku Azam Shah and Israf Ali, Daud Ahmad (2008) Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia, 79 (7-8). pp. 557-561. ISSN 0367-326X; ESSN: 1873-6971 10.1016/j.fitote.2008.06.005 English |
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UPM IR |
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UPM IR |
| language |
English |
| description |
The aqueous extract of Ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. The results of the present study showed that intraperitoneal administration of the F. deltoidea leaves aqueous extract at the dose of 1, 50 and 100 mg/kg, 30 min prior to pain induction produced significant dose-dependent antinociceptive effect in all the models used, which indicating the presence of both central and peripherally mediated activities. Furthermore, the antinociceptive effect of the extract in the formalin and hot plate test was reversed by the non-selective opioid receptor antagonist naloxone suggesting that the endogenous opioid system is involved in its analgesic mechanism of action. Thus, the present results demonstrated that F. deltoidea leaves aqueous extract contains pharmacologically active constituents which possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions. |
| format |
Article |
| author |
Sulaiman, Mohd Roslan Hussain, Mohd. Khairi Zakaria, Zainul Amiruddin Somchit, M.N. Moin, Saidi Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad |
| spellingShingle |
Sulaiman, Mohd Roslan Hussain, Mohd. Khairi Zakaria, Zainul Amiruddin Somchit, M.N. Moin, Saidi Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. |
| author_facet |
Sulaiman, Mohd Roslan Hussain, Mohd. Khairi Zakaria, Zainul Amiruddin Somchit, M.N. Moin, Saidi Tengku Mohamad, Tengku Azam Shah Israf Ali, Daud Ahmad |
| author_sort |
Sulaiman, Mohd Roslan |
| title |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
|
| title_short |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
|
| title_full |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
|
| title_fullStr |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
|
| title_full_unstemmed |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
|
| title_sort |
evaluation of the antinociceptive activity of ficus deltoidea aqueous extract. |
| publisher |
Elsevier |
| publishDate |
2008 |
| _version_ |
1819293833428467712 |
| score |
13.4562235 |