Psychiatric manifestations in orthopedic patients on Celecoxib therapy

Introduction: The Cyclooxygenase-2 (COX-2) enzyme is responsible for the synthesis of prostaglandin which is responsible for inflammation and pain. Celecoxib a cyclooxygenase-2 inhibitor was first used as a non-steroidal anti-inflammatory drug in 1999. Celecoxib is as effective as NSAJDs but causes...

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Main Authors: Arumugam, Manohar, Md. Zain, Azhar
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, University Putra Malaysia 2010
Online Access:http://psasir.upm.edu.my/id/eprint/16387/1/Psychiatric%20Manifestations%20in%20Orthopedic%20Patients%20on%20Celecoxib%20Therapy.pdf
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spelling oai:psasir.upm.edu.my:16387 http://psasir.upm.edu.my/id/eprint/16387/ Psychiatric manifestations in orthopedic patients on Celecoxib therapy Arumugam, Manohar Md. Zain, Azhar Introduction: The Cyclooxygenase-2 (COX-2) enzyme is responsible for the synthesis of prostaglandin which is responsible for inflammation and pain. Celecoxib a cyclooxygenase-2 inhibitor was first used as a non-steroidal anti-inflammatory drug in 1999. Celecoxib is as effective as NSAJDs but causes less ulceration of the gastrointestinal tract, hence it is commonly used. It has been widely used in patients with osteoarthritis and rheumatoid arthritis. We present 3 cases of temporary psychiatric disorders associated with consumption of celecoxib, two of the patients presented with auditory hallucinations while one was diagnosed to be having depression. None had pre-existing psychiatric disorders or consumed alcohol or substance of abuse. All 3 patients recovered from their temporary psychiatric disorders after stopping celecoxib. Discussion: It is important to be aware of the psychiatric side effects when prescribing the drug for prolonged periods. Faculty of Medicine and Health Sciences, University Putra Malaysia 2010-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16387/1/Psychiatric%20Manifestations%20in%20Orthopedic%20Patients%20on%20Celecoxib%20Therapy.pdf Arumugam, Manohar and Md. Zain, Azhar (2010) Psychiatric manifestations in orthopedic patients on Celecoxib therapy. Malaysian Journal of Medicine and Health Sciences, 6 (2). pp. 41-42. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2010V06N2_OP06.pdf
institution UPM IR
collection UPM IR
language English
description Introduction: The Cyclooxygenase-2 (COX-2) enzyme is responsible for the synthesis of prostaglandin which is responsible for inflammation and pain. Celecoxib a cyclooxygenase-2 inhibitor was first used as a non-steroidal anti-inflammatory drug in 1999. Celecoxib is as effective as NSAJDs but causes less ulceration of the gastrointestinal tract, hence it is commonly used. It has been widely used in patients with osteoarthritis and rheumatoid arthritis. We present 3 cases of temporary psychiatric disorders associated with consumption of celecoxib, two of the patients presented with auditory hallucinations while one was diagnosed to be having depression. None had pre-existing psychiatric disorders or consumed alcohol or substance of abuse. All 3 patients recovered from their temporary psychiatric disorders after stopping celecoxib. Discussion: It is important to be aware of the psychiatric side effects when prescribing the drug for prolonged periods.
format Article
author Arumugam, Manohar
Md. Zain, Azhar
spellingShingle Arumugam, Manohar
Md. Zain, Azhar
Psychiatric manifestations in orthopedic patients on Celecoxib therapy
author_facet Arumugam, Manohar
Md. Zain, Azhar
author_sort Arumugam, Manohar
title Psychiatric manifestations in orthopedic patients on Celecoxib therapy
title_short Psychiatric manifestations in orthopedic patients on Celecoxib therapy
title_full Psychiatric manifestations in orthopedic patients on Celecoxib therapy
title_fullStr Psychiatric manifestations in orthopedic patients on Celecoxib therapy
title_full_unstemmed Psychiatric manifestations in orthopedic patients on Celecoxib therapy
title_sort psychiatric manifestations in orthopedic patients on celecoxib therapy
publisher Faculty of Medicine and Health Sciences, University Putra Malaysia
publishDate 2010
url http://psasir.upm.edu.my/id/eprint/16387/1/Psychiatric%20Manifestations%20in%20Orthopedic%20Patients%20on%20Celecoxib%20Therapy.pdf
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