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Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart

This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of...

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Hlavní autoři: Camalxaman, Siti Nazrina, Allaudin, Zeenathul Nazariah, Quah, Yi Wan, Loh, Hwei San, Hassan, Zuridah, Abdul Rahman, Sheikh Omar, Mohd Lila, Mohd Azmi
Médium: Článek
Jazyk:English
Vydáno: Malaysian Society of Parasitology and Tropical Medicine 2011
On-line přístup:http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf
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spelling oai:psasir.upm.edu.my:25420 http://psasir.upm.edu.my/id/eprint/25420/ Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart Camalxaman, Siti Nazrina Allaudin, Zeenathul Nazariah Quah, Yi Wan Loh, Hwei San Hassan, Zuridah Abdul Rahman, Sheikh Omar Mohd Lila, Mohd Azmi This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of a plausible immunological cross-reactivity between RCMV with its human counterpart which grounds substantial interest implying existence of conserved determinants between rat and human CMV polypeptides. The cross-reactive protein most likely represents an enveloped glycoprotein, though the precise identification and its degree of similarity needs to be evidently defined and further elucidated in forthcoming experiments. Malaysian Society of Parasitology and Tropical Medicine 2011-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf Camalxaman, Siti Nazrina and Allaudin, Zeenathul Nazariah and Quah, Yi Wan and Loh, Hwei San and Hassan, Zuridah and Abdul Rahman, Sheikh Omar and Mohd Lila, Mohd Azmi (2011) Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart. Tropical Biomedicine, 28 (3). pp. 661-667. ISSN 0127-5720 http://msptm.org/journal-vol-28-no-3/
institution UPM IR
collection UPM IR
language English
description This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of a plausible immunological cross-reactivity between RCMV with its human counterpart which grounds substantial interest implying existence of conserved determinants between rat and human CMV polypeptides. The cross-reactive protein most likely represents an enveloped glycoprotein, though the precise identification and its degree of similarity needs to be evidently defined and further elucidated in forthcoming experiments.
format Article
author Camalxaman, Siti Nazrina
Allaudin, Zeenathul Nazariah
Quah, Yi Wan
Loh, Hwei San
Hassan, Zuridah
Abdul Rahman, Sheikh Omar
Mohd Lila, Mohd Azmi
spellingShingle Camalxaman, Siti Nazrina
Allaudin, Zeenathul Nazariah
Quah, Yi Wan
Loh, Hwei San
Hassan, Zuridah
Abdul Rahman, Sheikh Omar
Mohd Lila, Mohd Azmi
Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
author_facet Camalxaman, Siti Nazrina
Allaudin, Zeenathul Nazariah
Quah, Yi Wan
Loh, Hwei San
Hassan, Zuridah
Abdul Rahman, Sheikh Omar
Mohd Lila, Mohd Azmi
author_sort Camalxaman, Siti Nazrina
title Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
title_short Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
title_full Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
title_fullStr Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
title_full_unstemmed Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
title_sort cross-reactivity of malaysian rat cytomegalovirus strains with its human counterpart
publisher Malaysian Society of Parasitology and Tropical Medicine
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf
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score 13.4562235

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