Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negativel...
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Taylor & Francis
2013
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oai:psasir.upm.edu.my:28677 http://psasir.upm.edu.my/id/eprint/28677/ Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negatively charged, with good drug encapsulation efficiencies (>50%) and average particle sizes <200 nm. Interestingly, all the nanoparticles exhibited dibasic release profiles with a starting burst release within the first 8 h, followed by a controlled release phase lasting four days. Thus, linamarin-loaded nanoparticles indicate a promising candidate for controlled drug release applications. Taylor & Francis 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/28677/1/Preparation%20and%20characterization%20of%20Poly.pdf Hussein, Ahmed S. and Ahmadun, Fakhru'l-Razi and Abdullah, Norhafizah (2013) Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release. International Journal of Polymer Analysis and Characterization, 18 (6). pp. 414-422. ISSN 1023-666X; ESSN: 1563-5341 10.1080/1023666X.2013.786864 |
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UPM IR |
| language |
English |
| description |
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with linamarin as a model drug were successfully prepared using the double emulsion solvent evaporation technique. The physicochemical characterization of the formulated nanoparticles revealed that they were spherical, nonaggregated, and negatively charged, with good drug encapsulation efficiencies (>50%) and average particle sizes <200 nm. Interestingly, all the nanoparticles exhibited dibasic release profiles with a starting burst release within the first 8 h, followed by a controlled release phase lasting four days. Thus, linamarin-loaded nanoparticles indicate a promising candidate for controlled drug release applications. |
| format |
Article |
| author |
Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah |
| spellingShingle |
Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| author_facet |
Hussein, Ahmed S. Ahmadun, Fakhru'l-Razi Abdullah, Norhafizah |
| author_sort |
Hussein, Ahmed S. |
| title |
Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_short |
Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_full |
Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_fullStr |
Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_full_unstemmed |
Preparation and characterization of Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with linamarin for controlled drug release |
| title_sort |
preparation and characterization of poly (d,l-lactide-co-glycolide) (plga) nanoparticles loaded with linamarin for controlled drug release |
| publisher |
Taylor & Francis |
| publishDate |
2013 |
| url |
http://psasir.upm.edu.my/id/eprint/28677/1/Preparation%20and%20characterization%20of%20Poly.pdf |
| _version_ |
1819295152919805952 |
| score |
13.4562235 |