Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways

The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin....

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Bibliographic Details
Main Authors: Jamaludin, Nazzatush Shimar, Goh, Zheng Jie, Cheah, Yoke Kqueen, Ang, Kok Pian, Sim, Jiun Horng, Khoo, Chai Hoon, Zainal Abidin, Mohd Fairuz, Abdul Halim, Siti Nadiah, Ng, Seik Weng, Seng, Hoi Ling, Tiekink, Edward Richard Tom
Format: Article
Published: Elsevier 2013