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Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period

Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40% oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic effects if consume during pregnancy. Twenty four Sprague dawley rats at e...

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Autores Principales: Alwi, Nur Azira, Sukardi, Sabrina
Formato: Artículo
Lenguaje:English
Publicado: International Institute for Science, Technology & Education 2013
Acceso en línea:http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf
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spelling oai:psasir.upm.edu.my:29789 http://psasir.upm.edu.my/id/eprint/29789/ Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period Alwi, Nur Azira Sukardi, Sabrina Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40% oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic effects if consume during pregnancy. Twenty four Sprague dawley rats at early gestation weighing about 200- 300g were randomized into four groups: Positive control group was orally administered with retinyl palmitate, negative control group with corn oil (vehicle), treatment group with 0.7 ml/kg body weight of the oil and the normal group was given distilled water. Females were paired overnight with male rats and presence of sperm in the vaginal smears indicated positive mating and considered pregnant day 1. Rats were dosed orally once daily from day 1 till day 7 of gestation. Maternal body weights were also recorded daily. Rats were euthanized by diethyl ether inhalation on day 8 and the uteri removed and stained with 1% ammonium sulphide. The number of implantation sites was counted and data obtained were analysed using SPSS. There is a significant reduction in number of implantation sites i.e., treatment groups, positive and negative control and normal group are 0.83±0.401, 4.5±0.428, 8.67±0.333, 9.17±0.307 respectively. There is also a significant difference between treatment and control group in maternal body weights. In addition, a high percentage (90%) of anti-implantation activity was recorded in treatment groups. The small number of implantation sites and high percentage of anti-implantation activity suggests that Jatropha curcas crude oil have anti-fertility effects when fed to pregnant rats during early gestation. International Institute for Science, Technology & Education 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf Alwi, Nur Azira and Sukardi, Sabrina (2013) Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period. Advances in Life Science and Technology, 14. pp. 1-6. ISSN 2224-7181; ESSN: 2225-062X http://www.iiste.org/Journals/index.php/ALST/article/view/8607
institution UPM IR
collection UPM IR
language English
description Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40% oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic effects if consume during pregnancy. Twenty four Sprague dawley rats at early gestation weighing about 200- 300g were randomized into four groups: Positive control group was orally administered with retinyl palmitate, negative control group with corn oil (vehicle), treatment group with 0.7 ml/kg body weight of the oil and the normal group was given distilled water. Females were paired overnight with male rats and presence of sperm in the vaginal smears indicated positive mating and considered pregnant day 1. Rats were dosed orally once daily from day 1 till day 7 of gestation. Maternal body weights were also recorded daily. Rats were euthanized by diethyl ether inhalation on day 8 and the uteri removed and stained with 1% ammonium sulphide. The number of implantation sites was counted and data obtained were analysed using SPSS. There is a significant reduction in number of implantation sites i.e., treatment groups, positive and negative control and normal group are 0.83±0.401, 4.5±0.428, 8.67±0.333, 9.17±0.307 respectively. There is also a significant difference between treatment and control group in maternal body weights. In addition, a high percentage (90%) of anti-implantation activity was recorded in treatment groups. The small number of implantation sites and high percentage of anti-implantation activity suggests that Jatropha curcas crude oil have anti-fertility effects when fed to pregnant rats during early gestation.
format Article
author Alwi, Nur Azira
Sukardi, Sabrina
spellingShingle Alwi, Nur Azira
Sukardi, Sabrina
Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
author_facet Alwi, Nur Azira
Sukardi, Sabrina
author_sort Alwi, Nur Azira
title Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
title_short Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
title_full Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
title_fullStr Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
title_full_unstemmed Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
title_sort anti implantation effects of jatropha curcas crude oil when fed to pregnant sprague dawley rats during the early gestation period
publisher International Institute for Science, Technology & Education
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf
_version_ 1819295260239462400
score 13.4562235

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