A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects

Background: It has long been postulated that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that could be responsible for...

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Main Authors: Md. Zain, Azhar, Jamil @ Osman, Zubaidah, Naing, Khin Ohnmar@ Noorjan, Zhuang, Candy Yi Jing, Tsang, Fai
Format: Article
Language:English
Published: BioMed Central 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29805/1/A%20pilot%20placebo.pdf
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spelling oai:psasir.upm.edu.my:29805 http://psasir.upm.edu.my/id/eprint/29805/ A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects Md. Zain, Azhar Jamil @ Osman, Zubaidah Naing, Khin Ohnmar@ Noorjan Zhuang, Candy Yi Jing Tsang, Fai Background: It has long been postulated that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that could be responsible for the action of diet on brain health and cognitive function. Here, through a double-blind, randomized, placebo-controlled trial, we asked if the newly discovered chicken meat ingredient-168 (CMI-168) could be beneficial to the cognitive function in healthy adults. Methods: Normal, healthy subjects were supplemented with either placebo or CMI-168 for 6 weeks. The subjects were given a series of cognitive tests to examine their levels of cognitive functioning at the beginning and end of supplementation, as well as two weeks after termination of supplementation. The combination of these tests, namely Digit Span Backwards, Letter-Number Sequencing, and the Rey Auditory Verbal Learning Test (RAVLT), was used to assess the subjects' attention and working memory. For all comparisons, the probability level of p < 0.05 was taken as statistically significant using repeated measure 2-way ANOVA followed by Bonferroni post-hoc test. Results: Overall, subjects supplemented with CMI-168 showed significantly (p < 0.01) better performance in all cognitive tests after 6 weeks' supplementation compared to control and such superior performance was maintained even 2 weeks after termination of supplementation. Conclusions: The present study reveals the cognition-enhancing properties of a recently developed chicken meat ingredient, likely arising from the promotion of attention and prefrontal cortex functions. BioMed Central 2013-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29805/1/A%20pilot%20placebo.pdf Md. Zain, Azhar and Jamil @ Osman, Zubaidah and Naing, Khin Ohnmar@ Noorjan and Zhuang, Candy Yi Jing and Tsang, Fai (2013) A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects. Nutrition Journal, 12. art. no. 121. pp. 1-9. ISSN 1475-2891; ESSN: 1475-2891 http://www.nutritionj.com/content/12/1/121/abstract 10.1186/1475-2891-12-121
institution UPM IR
collection UPM IR
language English
description Background: It has long been postulated that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that could be responsible for the action of diet on brain health and cognitive function. Here, through a double-blind, randomized, placebo-controlled trial, we asked if the newly discovered chicken meat ingredient-168 (CMI-168) could be beneficial to the cognitive function in healthy adults. Methods: Normal, healthy subjects were supplemented with either placebo or CMI-168 for 6 weeks. The subjects were given a series of cognitive tests to examine their levels of cognitive functioning at the beginning and end of supplementation, as well as two weeks after termination of supplementation. The combination of these tests, namely Digit Span Backwards, Letter-Number Sequencing, and the Rey Auditory Verbal Learning Test (RAVLT), was used to assess the subjects' attention and working memory. For all comparisons, the probability level of p < 0.05 was taken as statistically significant using repeated measure 2-way ANOVA followed by Bonferroni post-hoc test. Results: Overall, subjects supplemented with CMI-168 showed significantly (p < 0.01) better performance in all cognitive tests after 6 weeks' supplementation compared to control and such superior performance was maintained even 2 weeks after termination of supplementation. Conclusions: The present study reveals the cognition-enhancing properties of a recently developed chicken meat ingredient, likely arising from the promotion of attention and prefrontal cortex functions.
format Article
author Md. Zain, Azhar
Jamil @ Osman, Zubaidah
Naing, Khin Ohnmar@ Noorjan
Zhuang, Candy Yi Jing
Tsang, Fai
spellingShingle Md. Zain, Azhar
Jamil @ Osman, Zubaidah
Naing, Khin Ohnmar@ Noorjan
Zhuang, Candy Yi Jing
Tsang, Fai
A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
author_facet Md. Zain, Azhar
Jamil @ Osman, Zubaidah
Naing, Khin Ohnmar@ Noorjan
Zhuang, Candy Yi Jing
Tsang, Fai
author_sort Md. Zain, Azhar
title A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
title_short A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
title_full A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
title_fullStr A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
title_full_unstemmed A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
title_sort pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects
publisher BioMed Central
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29805/1/A%20pilot%20placebo.pdf
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