Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications
The preparation of magnetic nanoparticles coated with chitosan-prindopril erbumine was accomplished and confirmed by X-ray diffraction, TEM, magnetic measurements, thermal analysis and infrared spectroscopic studies. X-ray diffraction and TEM results demonstrated that the magnetic nanoparticles were...
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Multidisciplinary Digital Publishing Institute
2013
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oai:psasir.upm.edu.my:30281 http://psasir.upm.edu.my/id/eprint/30281/ Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications Dorniani, Dena Hussein, Mohd. Zobir Kura, Aminu Umar Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah The preparation of magnetic nanoparticles coated with chitosan-prindopril erbumine was accomplished and confirmed by X-ray diffraction, TEM, magnetic measurements, thermal analysis and infrared spectroscopic studies. X-ray diffraction and TEM results demonstrated that the magnetic nanoparticles were pure iron oxide phase, having a spherical shape with a mean diameter of 6 nm, compared to 15 nm after coating with chitosan-prindopril erbumine (FCPE). Fourier transform infrared spectroscopy study shows that the coating of iron oxide nanoparticles takes place due to the presence of some bands that were emerging after the coating process, which belong to the prindopril erbumine (PE). The thermal stability of the PE in an FCPE nanocomposite was remarkably enhanced. The release study showed that around 89% of PE could be released within about 93 hours by a phosphate buffer solution at pH 7.4, which was found to be of sustained manner governed by first order kinetic. Compared to the control (untreated), cell viability study in 3T3 cells at 72 h post exposure to both the nanoparticles and the pure drug was found to be sustained above 80% using different doses. Multidisciplinary Digital Publishing Institute 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30281/1/Sustained%20release%20of%20prindopril%20erbumine%20from%20its%20chitosan.pdf Dorniani, Dena and Hussein, Mohd. Zobir and Kura, Aminu Umar and Fakurazi, Sharida and Shaari, Abdul Halim and Ahmad, Zalinah (2013) Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications. International Journal of Molecular Sciences, 14 (12). pp. 23639-23653. ISSN 1661-6596; ESSN: 1422-0067 http://www.mdpi.com/1422-0067/14/12 10.3390/ijms141223639 English |
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English English |
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The preparation of magnetic nanoparticles coated with chitosan-prindopril erbumine was accomplished and confirmed by X-ray diffraction, TEM, magnetic measurements, thermal analysis and infrared spectroscopic studies. X-ray diffraction and TEM results demonstrated that the magnetic nanoparticles were pure iron oxide phase, having a spherical shape with a mean diameter of 6 nm, compared to 15 nm after coating with chitosan-prindopril erbumine (FCPE). Fourier transform infrared spectroscopy study shows that the coating of iron oxide nanoparticles takes place due to the presence of some bands that were emerging after the coating process, which belong to the prindopril erbumine (PE). The thermal stability of the PE in an FCPE nanocomposite was remarkably enhanced. The release study showed that around 89% of PE could be released within about 93 hours by a phosphate buffer solution at pH 7.4, which was found to be of sustained manner governed by first order kinetic. Compared to the control (untreated), cell viability study in 3T3 cells at 72 h post exposure to both the nanoparticles and the pure drug was found to be sustained above 80% using different doses. |
| format |
Article |
| author |
Dorniani, Dena Hussein, Mohd. Zobir Kura, Aminu Umar Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| spellingShingle |
Dorniani, Dena Hussein, Mohd. Zobir Kura, Aminu Umar Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| author_facet |
Dorniani, Dena Hussein, Mohd. Zobir Kura, Aminu Umar Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| author_sort |
Dorniani, Dena |
| title |
Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| title_short |
Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| title_full |
Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| title_fullStr |
Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| title_full_unstemmed |
Sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| title_sort |
sustained release of prindopril erbumine from its chitosan-coated magnetic nanoparticles for biomedical applications |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2013 |
| url |
http://psasir.upm.edu.my/id/eprint/30281/1/Sustained%20release%20of%20prindopril%20erbumine%20from%20its%20chitosan.pdf |
| _version_ |
1819295307607834624 |
| score |
13.4562235 |