Hypoxia inducible factor (HIF) activity reporter cell line

The present invention relates to the construction of a new hypoxia inducible factor (HIF) responsive reporter gene construct, the genetic constructs and vectors containing the same. Further, the present invention relates to a stable cell line comprising the HIF responsive reporter construct, as well...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Shafee, Norazizah, Stanbridge, Eric J., Yusoff, Khatijah, Sien, Yei Liew
التنسيق: Patent
منشور في: 2012
الوسوم: إضافة وسم
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الوصف
الملخص:The present invention relates to the construction of a new hypoxia inducible factor (HIF) responsive reporter gene construct, the genetic constructs and vectors containing the same. Further, the present invention relates to a stable cell line comprising the HIF responsive reporter construct, as well as methods and uses of the inventive constructs and cell lines to identify modulators of HIF activity.