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Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes

Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in sheep and goats and is characterized by the development of pyogranulomas in the lymph nodes and organs. This study was designed to measure the concentration of inflammatory cytokines (IL-1β & IL-6) in experimen...

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Autores Principales: A. M., Othman, Abdullah, Faez Firdaus Jesse, Mohd Nordi, Nur Adza Rina, Yusuf, Ilyasu, Saad, Mohd Zamri, Haron, Abdul Wahid, Saharee, Abdul Aziz, Mohd Lila, Mohd Azmi
Formato: Artículo
Lenguaje:English
Publicado: KPK Publishers 2014
Acceso en línea:http://psasir.upm.edu.my/id/eprint/35247/1/Responses%20of%20inflammatory%20cytokines%20in%20non-pregnant%20Boer%20does%20inoculated%20with%20Corynebacterium%20pseudotuberculosis%20via%20various%20routes.pdf
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spelling oai:psasir.upm.edu.my:35247 http://psasir.upm.edu.my/id/eprint/35247/ Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes A. M., Othman Abdullah, Faez Firdaus Jesse Mohd Nordi, Nur Adza Rina Yusuf, Ilyasu Saad, Mohd Zamri Haron, Abdul Wahid Saharee, Abdul Aziz Mohd Lila, Mohd Azmi Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in sheep and goats and is characterized by the development of pyogranulomas in the lymph nodes and organs. This study was designed to measure the concentration of inflammatory cytokines (IL-1β & IL-6) in experimental non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis through various routes. Little is known about the concentration of IL-1β and IL-6 in different routes of infection caused by the organism. A total of twenty healthy non-pregnant Boer does were divided into 4 groups (A-D) of 5 does per groups. Three groups (A-C) were inoculated with 107cfu/1ml of live Corynebacterium pseudotuberculosis through intradermal, intranasal and oral routes respectively, while group D was kept unexposed. Following infection, blood samples were collected from the jugular vein between three days interval period for the analysis of IL-1β and IL-6. A significant increase (P<0.05) in IL-1β was observed through intranasal, intradermal and oral route compared to the control group. Significant increase in IL-1β and IL-6 was observed through intranasal route compared to other routes. This study, therefore, highlights the effects of inflammatory cytokines (IL-1β andIL-6) in caseous lymphadenitis infection. KPK Publishers 2014 Article NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35247/1/Responses%20of%20inflammatory%20cytokines%20in%20non-pregnant%20Boer%20does%20inoculated%20with%20Corynebacterium%20pseudotuberculosis%20via%20various%20routes.pdf A. M., Othman and Abdullah, Faez Firdaus Jesse and Mohd Nordi, Nur Adza Rina and Yusuf, Ilyasu and Saad, Mohd Zamri and Haron, Abdul Wahid and Saharee, Abdul Aziz and Mohd Lila, Mohd Azmi (2014) Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes. Research Opinions in Animal & Veterinary Sciences, 4 (11). pp. 597-600. ISSN 2221-1896; ESSN: 2223-0343 http://www.roavs.com/Abstract/Issue-11-2014/597-600.htm
institution UPM IR
collection UPM IR
language English
description Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis in sheep and goats and is characterized by the development of pyogranulomas in the lymph nodes and organs. This study was designed to measure the concentration of inflammatory cytokines (IL-1β & IL-6) in experimental non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis through various routes. Little is known about the concentration of IL-1β and IL-6 in different routes of infection caused by the organism. A total of twenty healthy non-pregnant Boer does were divided into 4 groups (A-D) of 5 does per groups. Three groups (A-C) were inoculated with 107cfu/1ml of live Corynebacterium pseudotuberculosis through intradermal, intranasal and oral routes respectively, while group D was kept unexposed. Following infection, blood samples were collected from the jugular vein between three days interval period for the analysis of IL-1β and IL-6. A significant increase (P<0.05) in IL-1β was observed through intranasal, intradermal and oral route compared to the control group. Significant increase in IL-1β and IL-6 was observed through intranasal route compared to other routes. This study, therefore, highlights the effects of inflammatory cytokines (IL-1β andIL-6) in caseous lymphadenitis infection.
format Article
author A. M., Othman
Abdullah, Faez Firdaus Jesse
Mohd Nordi, Nur Adza Rina
Yusuf, Ilyasu
Saad, Mohd Zamri
Haron, Abdul Wahid
Saharee, Abdul Aziz
Mohd Lila, Mohd Azmi
spellingShingle A. M., Othman
Abdullah, Faez Firdaus Jesse
Mohd Nordi, Nur Adza Rina
Yusuf, Ilyasu
Saad, Mohd Zamri
Haron, Abdul Wahid
Saharee, Abdul Aziz
Mohd Lila, Mohd Azmi
Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
author_facet A. M., Othman
Abdullah, Faez Firdaus Jesse
Mohd Nordi, Nur Adza Rina
Yusuf, Ilyasu
Saad, Mohd Zamri
Haron, Abdul Wahid
Saharee, Abdul Aziz
Mohd Lila, Mohd Azmi
author_sort A. M., Othman
title Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
title_short Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
title_full Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
title_fullStr Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
title_full_unstemmed Responses of inflammatory cytokines in non-pregnant Boer does inoculated with Corynebacterium pseudotuberculosis via various routes
title_sort responses of inflammatory cytokines in non-pregnant boer does inoculated with corynebacterium pseudotuberculosis via various routes
publisher KPK Publishers
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35247/1/Responses%20of%20inflammatory%20cytokines%20in%20non-pregnant%20Boer%20does%20inoculated%20with%20Corynebacterium%20pseudotuberculosis%20via%20various%20routes.pdf
_version_ 1819295765944598528
score 13.4562235

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