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Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)

Studies on the teratogenicity effects of Jatropha curcas has been reported in pregnant rats. This study was conducted to observe whether feeding Jatropha curcas seeds crude oil (JCO)to pregnant rats during early and late gestation will cause fetal skeletal malformations....

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Asıl Yazarlar: Abdul Mutalib, Noor Haziyah, Samat, Yon Thannia, Sukardi, Sabrina
Materyal Türü: Makale
Baskı/Yayın Bilgisi: Centre for Enhancing Knowledge 2014
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id oai:psasir.upm.edu.my:35390
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spelling oai:psasir.upm.edu.my:35390 http://psasir.upm.edu.my/id/eprint/35390/ Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO) Abdul Mutalib, Noor Haziyah Samat, Yon Thannia Sukardi, Sabrina Studies on the teratogenicity effects of Jatropha curcas has been reported in pregnant rats. This study was conducted to observe whether feeding Jatropha curcas seeds crude oil (JCO)to pregnant rats during early and late gestation will cause fetal skeletal malformations. A hundred sexually mature female rats were divided equally into 2 groups: early and late gestation. Each group was then subdivided equally into 5 groups: positive control (retinylpalmitate), vehicle control (corn oil), low dose (0.175ml/kg), medium dose (0.35ml/kg) and high dose (0.7ml/kg) of JCO. Rats were mated overnight and positive pregnant ratswere treated on days 1-7 (early group) and days 8-14 (late group). Rats were sacrificed on day 21 of pregnancy. Fetuses were processed accordingly and any skeletal malformations were recorded. Data show fetuses in high treatment group were significantly smaller as compared to other groups. Skeletal abnormalities in fetuses from all JCO treated groups were observed suggesting fetotoxicity. Centre for Enhancing Knowledge 2014-12 Article PeerReviewed Abdul Mutalib, Noor Haziyah and Samat, Yon Thannia and Sukardi, Sabrina (2014) Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO). European International Journal of Science and Technology, 3 (9). pp. 54-60. ISSN 2304-9693 http://www.eijst.org.uk/December2014
institution UPM IR
collection UPM IR
description Studies on the teratogenicity effects of Jatropha curcas has been reported in pregnant rats. This study was conducted to observe whether feeding Jatropha curcas seeds crude oil (JCO)to pregnant rats during early and late gestation will cause fetal skeletal malformations. A hundred sexually mature female rats were divided equally into 2 groups: early and late gestation. Each group was then subdivided equally into 5 groups: positive control (retinylpalmitate), vehicle control (corn oil), low dose (0.175ml/kg), medium dose (0.35ml/kg) and high dose (0.7ml/kg) of JCO. Rats were mated overnight and positive pregnant ratswere treated on days 1-7 (early group) and days 8-14 (late group). Rats were sacrificed on day 21 of pregnancy. Fetuses were processed accordingly and any skeletal malformations were recorded. Data show fetuses in high treatment group were significantly smaller as compared to other groups. Skeletal abnormalities in fetuses from all JCO treated groups were observed suggesting fetotoxicity.
format Article
author Abdul Mutalib, Noor Haziyah
Samat, Yon Thannia
Sukardi, Sabrina
spellingShingle Abdul Mutalib, Noor Haziyah
Samat, Yon Thannia
Sukardi, Sabrina
Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
author_facet Abdul Mutalib, Noor Haziyah
Samat, Yon Thannia
Sukardi, Sabrina
author_sort Abdul Mutalib, Noor Haziyah
title Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
title_short Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
title_full Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
title_fullStr Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
title_full_unstemmed Skeletal malformation of fetuses from pregnant Sprague Dawley rats fed Jatropha curcas crude oil (JCO)
title_sort skeletal malformation of fetuses from pregnant sprague dawley rats fed jatropha curcas crude oil (jco)
publisher Centre for Enhancing Knowledge
publishDate 2014
_version_ 1819295781617664000
score 13.4562235

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