Staff View: A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women

A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women

Background: The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to CVD development. Methods: In this study, Nigella sativa was evaluated for its...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamad Ibrahim, Ramlah, Hamdan, Nurul Syima, Mahmud, Rozi, Imam, Mustapha Umar, Mohd Saini, Suraini, Abdul Rashid, Saiful Nizam, Abd Ghafar, Siti Aisyah, Abd Latiff, Latiffah, Ismail, Maznah
Format:	Article
Language:	English
Published:	BioMed Central 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/36243/1/A%20randomised%20controlled%20trial%20on%20hypolipidemic%20effects%20of%20Nigella%20Sativa%20seeds%20powder%20in%20menopausal%20women.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:psasir.upm.edu.my:36243
record_format	eprints
spelling	oai:psasir.upm.edu.my:36243 http://psasir.upm.edu.my/id/eprint/36243/ A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women Mohamad Ibrahim, Ramlah Hamdan, Nurul Syima Mahmud, Rozi Imam, Mustapha Umar Mohd Saini, Suraini Abdul Rashid, Saiful Nizam Abd Ghafar, Siti Aisyah Abd Latiff, Latiffah Ismail, Maznah Background: The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to CVD development. Methods: In this study, Nigella sativa was evaluated for its hypolipidemic effects among menopausal women. In a randomised trial, hyperlipidemic menopausal women were assigned to treatment (n = 19) or placebo groups (n = 18), and given N. sativa or placebo for two months after their informed consents were sought. At baseline, blood samples were taken and at one month intervals thereafter until one month after the end of the study. Results: The results showed that N. sativa significantly improved lipid profiles of menopausal women (decreased total cholesterol, low density lipoprotein cholesterol and triglyceride, and increased high density lipoprotein cholesterol) more than the placebo treatment over 2 months of intervention. One month after cessation of treatment, the lipid profiles in the N. sativa-treated group tended to change towards the pretreatment levels. Conclusions: N. sativa is thought to have multiple mechanisms of action and is cost-effective. Therefore, it could be used by menopausal women to remedy hypercholesterolemia, with likely more benefits than with single pharmacological agents that may cause side effects. The use of N. sativa as an alternative therapy for hypercholesterolemia could have profound impact on the management of CVD among menopausal women especially in countries where it is readily available. BioMed Central 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36243/1/A%20randomised%20controlled%20trial%20on%20hypolipidemic%20effects%20of%20Nigella%20Sativa%20seeds%20powder%20in%20menopausal%20women.pdf Mohamad Ibrahim, Ramlah and Hamdan, Nurul Syima and Mahmud, Rozi and Imam, Mustapha Umar and Mohd Saini, Suraini and Abdul Rashid, Saiful Nizam and Abd Ghafar, Siti Aisyah and Abd Latiff, Latiffah and Ismail, Maznah (2014) A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women. Journal of Translational Medicine, 12. art. no. 82. pp. 1-7. ISSN 1479-5876 http://www.translational-medicine.com/content/12/1/82/abstract 10.1186/1479-5876-12-82
institution	UPM IR
collection	UPM IR
language	English
description	Background: The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to CVD development. Methods: In this study, Nigella sativa was evaluated for its hypolipidemic effects among menopausal women. In a randomised trial, hyperlipidemic menopausal women were assigned to treatment (n = 19) or placebo groups (n = 18), and given N. sativa or placebo for two months after their informed consents were sought. At baseline, blood samples were taken and at one month intervals thereafter until one month after the end of the study. Results: The results showed that N. sativa significantly improved lipid profiles of menopausal women (decreased total cholesterol, low density lipoprotein cholesterol and triglyceride, and increased high density lipoprotein cholesterol) more than the placebo treatment over 2 months of intervention. One month after cessation of treatment, the lipid profiles in the N. sativa-treated group tended to change towards the pretreatment levels. Conclusions: N. sativa is thought to have multiple mechanisms of action and is cost-effective. Therefore, it could be used by menopausal women to remedy hypercholesterolemia, with likely more benefits than with single pharmacological agents that may cause side effects. The use of N. sativa as an alternative therapy for hypercholesterolemia could have profound impact on the management of CVD among menopausal women especially in countries where it is readily available.
format	Article
author	Mohamad Ibrahim, Ramlah Hamdan, Nurul Syima Mahmud, Rozi Imam, Mustapha Umar Mohd Saini, Suraini Abdul Rashid, Saiful Nizam Abd Ghafar, Siti Aisyah Abd Latiff, Latiffah Ismail, Maznah
spellingShingle	Mohamad Ibrahim, Ramlah Hamdan, Nurul Syima Mahmud, Rozi Imam, Mustapha Umar Mohd Saini, Suraini Abdul Rashid, Saiful Nizam Abd Ghafar, Siti Aisyah Abd Latiff, Latiffah Ismail, Maznah A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
author_facet	Mohamad Ibrahim, Ramlah Hamdan, Nurul Syima Mahmud, Rozi Imam, Mustapha Umar Mohd Saini, Suraini Abdul Rashid, Saiful Nizam Abd Ghafar, Siti Aisyah Abd Latiff, Latiffah Ismail, Maznah
author_sort	Mohamad Ibrahim, Ramlah
title	A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
title_short	A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
title_full	A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
title_fullStr	A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
title_full_unstemmed	A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
title_sort	randomised controlled trial on hypolipidemic effects of nigella sativa seeds powder in menopausal women
publisher	BioMed Central
publishDate	2014
url	http://psasir.upm.edu.my/id/eprint/36243/1/A%20randomised%20controlled%20trial%20on%20hypolipidemic%20effects%20of%20Nigella%20Sativa%20seeds%20powder%20in%20menopausal%20women.pdf
_version_	1698901543508508672
score	12.907076

A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women

Similar Items