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Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications

Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanopa...

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Hlavní autoři: Dorniani, Dena, Kura, Aminu Umar, Hussein, Mohd Zobir, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah
Médium: Článek
Jazyk:English
Vydáno: Springer 2014
On-line přístup:http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf
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spelling oai:psasir.upm.edu.my:36908 http://psasir.upm.edu.my/id/eprint/36908/ Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications Dorniani, Dena Kura, Aminu Umar Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs–PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG–PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet–visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs–PEG–PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes. Springer 2014-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf Dorniani, Dena and Kura, Aminu Umar and Hussein, Mohd Zobir and Fakurazi, Sharida and Shaari, Abdul Halim and Ahmad, Zalinah (2014) Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications. Journal of Materials Science, 49 (24). pp. 8487-8497. ISSN 0022-2461; ESSN:1573-4803 10.1007/s10853-014-8559-7
institution UPM IR
collection UPM IR
language English
description Iron oxide nanoparticles (FNPs) were synthesized due to low toxicity and their ability to immobilize biological materials on their surfaces by the coprecipitation of iron salts in ammonia hydroxide followed by coating it with polyethylene glycol (PEG) to minimize the aggregation of iron oxide nanoparticles and enhance the effect of nanoparticles for biological applications. Then, the FNPs–PEG was loaded with perindopril erbumine (PE), an antihypertensive compound to form a new nanocomposite (FPEGPE). Transmission electron microscopy results showed that there are no significant differences between the sizes of FNPs and FPEGPE nanocomposite. The existence of PEG–PE was supported by the FTIR and TGA analyses. The PE loading (10.3 %) and the release profiles from FPEGPE nanocomposite were estimated using ultraviolet–visible spectroscopy which showed that up to 60.8 and 83.1 % of the adsorbed drug was released in 4223 and 1231 min at pH 7.4 and 4.8, respectively. However, the release of PE was completed very fast from a physical mixture (FNPs–PEG–PE) after 5 and 7 min at pH 4.8 and 7.4, respectively, which reveals that the release of PE from the physical mixture is not in the sustained-release manner. Cytotoxicity study showed that free PE presented slightly higher toxicity than the FNPs and FPEGPE nanocomposite. Therefore, the decrease toxicity against mouse normal fibroblast (3T3) cell lines prospective of this nanocomposite together with controlled-release behavior provided evidence of the possible beneficial biological activities of this new nanocomposite for nanopharmaceutical applications for both oral and non-oral routes.
format Article
author Dorniani, Dena
Kura, Aminu Umar
Hussein, Mohd Zobir
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
spellingShingle Dorniani, Dena
Kura, Aminu Umar
Hussein, Mohd Zobir
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
author_facet Dorniani, Dena
Kura, Aminu Umar
Hussein, Mohd Zobir
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
author_sort Dorniani, Dena
title Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
title_short Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
title_full Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
title_fullStr Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
title_full_unstemmed Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications
title_sort controlled-release formulation of perindopril erbumine loaded peg-coated magnetite nanoparticles for biomedical applications
publisher Springer
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/36908/1/Controlled.pdf
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score 13.4562235

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