Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens
The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives...
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MDPI
2019
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| Διαθέσιμο Online: | http://psasir.upm.edu.my/id/eprint/38297/1/38297.pdf |
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oai:psasir.upm.edu.my:38297 http://psasir.upm.edu.my/id/eprint/38297/ Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens Mahizan, Nik Nur Amirah Yang, Shun Kai Moo, Chew Li Song, Adelene Ai Lian Chong, Chou Min Chong, Chun Wie Abushelaibi, Aisha Lim, Erin Swee Hua Lai, Kok Song The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38297/1/38297.pdf Mahizan, Nik Nur Amirah and Yang, Shun Kai and Moo, Chew Li and Song, Adelene Ai Lian and Chong, Chou Min and Chong, Chun Wie and Abushelaibi, Aisha and Lim, Erin Swee Hua and Lai, Kok Song (2019) Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens. Molecules, 24 (14). art. no. 2631. pp. 1-21. ISSN 1420-3049 https://www.mdpi.com/1420-3049/24/14/2631 10.3390/molecules24142631 |
| institution |
UPM IR |
| collection |
UPM IR |
| language |
English |
| description |
The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed. |
| format |
Article |
| author |
Mahizan, Nik Nur Amirah Yang, Shun Kai Moo, Chew Li Song, Adelene Ai Lian Chong, Chou Min Chong, Chun Wie Abushelaibi, Aisha Lim, Erin Swee Hua Lai, Kok Song |
| spellingShingle |
Mahizan, Nik Nur Amirah Yang, Shun Kai Moo, Chew Li Song, Adelene Ai Lian Chong, Chou Min Chong, Chun Wie Abushelaibi, Aisha Lim, Erin Swee Hua Lai, Kok Song Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| author_facet |
Mahizan, Nik Nur Amirah Yang, Shun Kai Moo, Chew Li Song, Adelene Ai Lian Chong, Chou Min Chong, Chun Wie Abushelaibi, Aisha Lim, Erin Swee Hua Lai, Kok Song |
| author_sort |
Mahizan, Nik Nur Amirah |
| title |
Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| title_short |
Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| title_full |
Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| title_fullStr |
Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| title_full_unstemmed |
Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens |
| title_sort |
terpene derivatives as a potential agent against antimicrobial resistance (amr) pathogens |
| publisher |
MDPI |
| publishDate |
2019 |
| url |
http://psasir.upm.edu.my/id/eprint/38297/1/38297.pdf |
| _version_ |
1819296061079945216 |
| score |
13.4562235 |