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Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica

In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extr...

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Huvudupphovsmän: Jalil, Juriyati, Jantan, Ibrahim, Shaari, Khozirah, Abdul Rafi, Iftikhar Ahmad
Materialtyp: Artikel
Språk:English
Publicerad: Taylor & Francis 2004
Länkar:http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf
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spelling oai:psasir.upm.edu.my:40443 http://psasir.upm.edu.my/id/eprint/40443/ Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica Jalil, Juriyati Jantan, Ibrahim Shaari, Khozirah Abdul Rafi, Iftikhar Ahmad In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extract showed inhibitory activity of 53.9% and its ethyl acetate, n-butanol, and methanol fractions exhibited 48.6%, 39.0%, and 22.0% inhibition, respectively. Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of a new alkenylresorcinol, 5-(Z-heptadec-4′-enyl)resorcinol, together with 5-pentadecylresorcinol. The alkenylresorcinol showed a strong inhibition with an IC50 value of 7.1 µM. The structures of the compounds were elucidated by spectroscopic techniques. Taylor & Francis 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf Jalil, Juriyati and Jantan, Ibrahim and Shaari, Khozirah and Abdul Rafi, Iftikhar Ahmad (2004) Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica. Pharmaceutical Biology, 42 (6). pp. 457-461. ISSN 1388-0209; ESSN: 1744-5116 http://www.tandfonline.com/doi/abs/10.1080/13880200490886157 10.1080/13880200490886157
institution UPM IR
collection UPM IR
language English
description In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extract showed inhibitory activity of 53.9% and its ethyl acetate, n-butanol, and methanol fractions exhibited 48.6%, 39.0%, and 22.0% inhibition, respectively. Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of a new alkenylresorcinol, 5-(Z-heptadec-4′-enyl)resorcinol, together with 5-pentadecylresorcinol. The alkenylresorcinol showed a strong inhibition with an IC50 value of 7.1 µM. The structures of the compounds were elucidated by spectroscopic techniques.
format Article
author Jalil, Juriyati
Jantan, Ibrahim
Shaari, Khozirah
Abdul Rafi, Iftikhar Ahmad
spellingShingle Jalil, Juriyati
Jantan, Ibrahim
Shaari, Khozirah
Abdul Rafi, Iftikhar Ahmad
Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
author_facet Jalil, Juriyati
Jantan, Ibrahim
Shaari, Khozirah
Abdul Rafi, Iftikhar Ahmad
author_sort Jalil, Juriyati
title Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
title_short Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
title_full Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
title_fullStr Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
title_full_unstemmed Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
title_sort bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from ardisia elliptica
publisher Taylor & Francis
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf
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