PIK3CA gene mutations in breast carcinoma in Malaysian patients
Somatic mutations of phosphoinositide-3-kinase, catalytic, α; PIK3CA gene have been reported in several types of human cancers. The majority of the PIK3CA mutations map to the three “hot spots” — E542 K and E545 K in the helical (exon 9) and H1047R in the kinase (exon 20) domains of the p110α. These...
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