Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h, 7a, 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC50...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46477/1/Synthesis%2C%20biological%20evaluation%20and%20QSAR%20studies%20of%20diarylpentanoid%20analogues%20as%20potential%20nitric%20oxide%20inhibitors.pdf |
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