প্রচ্ছদ

Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals

The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, w...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Zakaria, Zainul Amiruddin, Raden Mohd Nor, Raden Nur Suraya, Gopalan, Hanan Kumar, Abdul Ghani, Zuleen Delina Fasya, Sulaiman, Mohd Roslan, Ganeson, Rathna Devi, Mat Jais, Abdul Manan, Somchit, Muhammad Nazrul, Abdullah, Fatimah Corazon
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: NRC Research Press 2006
অনলাইন ব্যবহার করুন:http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf
ট্যাগগুলো: ট্যাগ যুক্ত করুন
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
id oai:psasir.upm.edu.my:48579
record_format eprints
spelling oai:psasir.upm.edu.my:48579 http://psasir.upm.edu.my/id/eprint/48579/ Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals Zakaria, Zainul Amiruddin Raden Mohd Nor, Raden Nur Suraya Gopalan, Hanan Kumar Abdul Ghani, Zuleen Delina Fasya Sulaiman, Mohd Roslan Ganeson, Rathna Devi Mat Jais, Abdul Manan Somchit, Muhammad Nazrul Abdullah, Fatimah Corazon The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments. NRC Research Press 2006 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf Zakaria, Zainul Amiruddin and Raden Mohd Nor, Raden Nur Suraya and Gopalan, Hanan Kumar and Abdul Ghani, Zuleen Delina Fasya and Sulaiman, Mohd Roslan and Ganeson, Rathna Devi and Mat Jais, Abdul Manan and Somchit, Muhammad Nazrul and Abdullah, Fatimah Corazon (2006) Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Canadian Journal of Physiology and Pharmacology, 84 (12). pp. 1291-1299. ISSN 0008-4212; ESSN: 1205-7541 http://www.nrcresearchpress.com/doi/abs/10.1139/y06-083?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.V8eUnTVrsZM 10.1139/y06-083
institution UPM IR
collection UPM IR
language English
description The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments.
format Article
author Zakaria, Zainul Amiruddin
Raden Mohd Nor, Raden Nur Suraya
Gopalan, Hanan Kumar
Abdul Ghani, Zuleen Delina Fasya
Sulaiman, Mohd Roslan
Ganeson, Rathna Devi
Mat Jais, Abdul Manan
Somchit, Muhammad Nazrul
Abdullah, Fatimah Corazon
spellingShingle Zakaria, Zainul Amiruddin
Raden Mohd Nor, Raden Nur Suraya
Gopalan, Hanan Kumar
Abdul Ghani, Zuleen Delina Fasya
Sulaiman, Mohd Roslan
Ganeson, Rathna Devi
Mat Jais, Abdul Manan
Somchit, Muhammad Nazrul
Abdullah, Fatimah Corazon
Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
author_facet Zakaria, Zainul Amiruddin
Raden Mohd Nor, Raden Nur Suraya
Gopalan, Hanan Kumar
Abdul Ghani, Zuleen Delina Fasya
Sulaiman, Mohd Roslan
Ganeson, Rathna Devi
Mat Jais, Abdul Manan
Somchit, Muhammad Nazrul
Abdullah, Fatimah Corazon
author_sort Zakaria, Zainul Amiruddin
title Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
title_short Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
title_full Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
title_fullStr Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
title_full_unstemmed Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
title_sort antinociceptive, anti-inflammatory and antipyretic properties of melastoma malabathricum leaves aqueous extract in experimental animals
publisher NRC Research Press
publishDate 2006
url http://psasir.upm.edu.my/id/eprint/48579/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20properties%20of%20Melastoma%20malabathricum%20leaves%20aqueous%20extract%20in%20experimental%20animals.pdf
_version_ 1819296895788384256
score 13.4562235

অনুরূপ উপাদানগুলি