Hypoglycemic activity of Morinda citrifolia extract in normal and streptozotocin-induced diabetic rats
The hypoglycemic activity of Morinda citrifolia extract was tested through an acute and subchronic study. In the acute study, a single dose of M. citrifolia extract (0.25 g/kg) was orally administered to normal and diabetic rats for an oral glucose tolerance test. In the subchronic study, an aqueous...
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| Autori principali: | , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Malaysian Agricultural Research and Development Institute (MARDI)
2004
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| Accesso online: | http://psasir.upm.edu.my/id/eprint/48888/1/Hypoglycemic%20activity%20of%20Morinda%20citrifolia%20extract%20in%20normal%20and%20streptozotocin-induced%20diabetic%20rats.pdf |
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| Riassunto: | The hypoglycemic activity of Morinda citrifolia extract was tested through an acute and subchronic study. In the acute study, a single dose of M. citrifolia extract (0.25 g/kg) was orally administered to normal and diabetic rats for an oral glucose tolerance test. In the subchronic study, an aqueous extract of M. citrifolia in concentrations of 0.25 g/kg (low dose), 0.50 g/kg (medium dose) and 1.0 g/kg (high dose) of body weight were orally administered to normal and diabetic rats for 6 weeks. Glibenclamide, a reference drug was also orally administered to the diabetic rats at a dosage of 5 mg/kg for both studies. In the acute hypoglycemic study, the blood glucose level in normal and diabetic rats did not change significantly as compared to their relative controls. A similar result was also observed in the glibenclamide-treated rats. In the subchronic study, blood glucose levels were reduced significantly (p <0.05) in normal and diabetic rats at medium (0.5 g/kg) and high (1.0 g/kg) dose of M. citrifolia extracts as compared to the controls. Supplementation of glibenclamide also reduced the glucose level significantly (p <0.05) in diabetic rats. |
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