Komentarji: SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

SRJ09 (3,19-(2-bromobenzylidene)andrographolide), a semisynthetic andrographolide (AGP) derivative, was shown to induce G1 cell cycle arrest and eventually apoptosis in breast and colon cancer cell lines. The present investigation was carried out to elucidate the mechanisms cell cycle arrest and apo...

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Bibliografske podrobnosti
Main Authors:	Wong, Charng Choon, Lim, Siang Hui, Sagineedu, Sreenivasa Rao, Lajis, Nordin, Stanslas, Johnson
Format:	Article
Jezik:	English
Izdano:	Elsevier 2016
Teme:	Andrographolide derivatives; p21; CDK-4; Apoptosis; Cell cycle arrest; Pharmacokinetics
Online dostop:	http://psasir.upm.edu.my/id/eprint/53871/1/SRJ09%2C%20a%20promising%20anticancer%20drug%20lead.pdf
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SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy

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