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Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain

Background: Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerum-bone (Zer), a sesquiterpene compound isolated from the rhizomes of a Southeast Asian ginger plant, Zingi...

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Hauptverfasser: Gopalsamy, Banulata, Omar Farouk, Ahmad Akira, Tengku Mohamad, Tengku Azam Shah, Sulaiman, Mohd Roslan, Perimal, Enoch Kumar
Format: Artikel
Sprache:English
Veröffentlicht: Dove Medical Press 2017
Online Zugang:http://psasir.upm.edu.my/id/eprint/60876/1/Antiallodynic%20and%20antihyperalgesic%20activities%20of%20zerumbone%20via%20the%20suppression%20of%20IL-1%CE%B2%2C%20IL-6%20and%20TNF-%CE%B1%20in%20a%20mice%20model%20of%20neuropathic%20pain.pdf
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spelling oai:psasir.upm.edu.my:60876 http://psasir.upm.edu.my/id/eprint/60876/ Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain Gopalsamy, Banulata Omar Farouk, Ahmad Akira Tengku Mohamad, Tengku Azam Shah Sulaiman, Mohd Roslan Perimal, Enoch Kumar Background: Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerum-bone (Zer), a sesquiterpene compound isolated from the rhizomes of a Southeast Asian ginger plant, Zingiber zerumbet (L.) Roscoe ex Smith. (Zingiberaceae), showed antinociceptive and antiinflammatory properties when previously tested on models of nociception and inflammation.Objective:This study investigated the effects of prophylactic administration of zerumbone on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain.Methods:Intraperitoneal administration of Zer (5–50 mg/kg) from day 1 post-surgery was car-ried out to identify the onset and progression of the pain condition. Responses toward mechanical and cold allodynia, and mechanical and thermal hyperalgesia were assessed on days 3, 5, 7, 9, 11, and 14 post-surgery. Blood plasma and spinal cord levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and IL-10 were screened using enzyme-linked immunosorbent assay on day 15.Results: Zer (10 and 50 mg/kg) attenuated pain symptoms on all days of behavioral testing without any signs of sedation in the rotarod test. ED50 values for mechanical allodynia, cold allodynia, thermal hyperalgesia, and mechanical hyperalgesia were 9.25, 9.507, 8.289, and 9.801 mg/kg, respectively. Blood plasma and spinal levels of IL-1β, IL-6, and tumor necrosis factor-αbut not IL-10 were significantly (p<0.05) suppressed by zer treatment. Discussion and conclusion:Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators. Zer may prove to be a novel and beneficial alternative for the management of neuropathic pain. Dove Medical Press 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60876/1/Antiallodynic%20and%20antihyperalgesic%20activities%20of%20zerumbone%20via%20the%20suppression%20of%20IL-1%CE%B2%2C%20IL-6%20and%20TNF-%CE%B1%20in%20a%20mice%20model%20of%20neuropathic%20pain.pdf Gopalsamy, Banulata and Omar Farouk, Ahmad Akira and Tengku Mohamad, Tengku Azam Shah and Sulaiman, Mohd Roslan and Perimal, Enoch Kumar (2017) Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain. Journal of Pain Research, 10. 2605 - 2619. ISSN 1178-7090; ESSN: 1178-7090 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685132/pdf/jpr-10-2605.pdf 10.2147/JPR.S143024
institution UPM IR
collection UPM IR
language English
description Background: Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerum-bone (Zer), a sesquiterpene compound isolated from the rhizomes of a Southeast Asian ginger plant, Zingiber zerumbet (L.) Roscoe ex Smith. (Zingiberaceae), showed antinociceptive and antiinflammatory properties when previously tested on models of nociception and inflammation.Objective:This study investigated the effects of prophylactic administration of zerumbone on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain.Methods:Intraperitoneal administration of Zer (5–50 mg/kg) from day 1 post-surgery was car-ried out to identify the onset and progression of the pain condition. Responses toward mechanical and cold allodynia, and mechanical and thermal hyperalgesia were assessed on days 3, 5, 7, 9, 11, and 14 post-surgery. Blood plasma and spinal cord levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and IL-10 were screened using enzyme-linked immunosorbent assay on day 15.Results: Zer (10 and 50 mg/kg) attenuated pain symptoms on all days of behavioral testing without any signs of sedation in the rotarod test. ED50 values for mechanical allodynia, cold allodynia, thermal hyperalgesia, and mechanical hyperalgesia were 9.25, 9.507, 8.289, and 9.801 mg/kg, respectively. Blood plasma and spinal levels of IL-1β, IL-6, and tumor necrosis factor-αbut not IL-10 were significantly (p<0.05) suppressed by zer treatment. Discussion and conclusion:Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators. Zer may prove to be a novel and beneficial alternative for the management of neuropathic pain.
format Article
author Gopalsamy, Banulata
Omar Farouk, Ahmad Akira
Tengku Mohamad, Tengku Azam Shah
Sulaiman, Mohd Roslan
Perimal, Enoch Kumar
spellingShingle Gopalsamy, Banulata
Omar Farouk, Ahmad Akira
Tengku Mohamad, Tengku Azam Shah
Sulaiman, Mohd Roslan
Perimal, Enoch Kumar
Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
author_facet Gopalsamy, Banulata
Omar Farouk, Ahmad Akira
Tengku Mohamad, Tengku Azam Shah
Sulaiman, Mohd Roslan
Perimal, Enoch Kumar
author_sort Gopalsamy, Banulata
title Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
title_short Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
title_full Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
title_fullStr Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
title_full_unstemmed Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6 and TNF-α in a mice model of neuropathic pain
title_sort antiallodynic and antihyperalgesic activities of zerumbone via the suppression of il-1β, il-6 and tnf-α in a mice model of neuropathic pain
publisher Dove Medical Press
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/60876/1/Antiallodynic%20and%20antihyperalgesic%20activities%20of%20zerumbone%20via%20the%20suppression%20of%20IL-1%CE%B2%2C%20IL-6%20and%20TNF-%CE%B1%20in%20a%20mice%20model%20of%20neuropathic%20pain.pdf
_version_ 1819298067485032448
score 13.4562235

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