Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients

Breast cancer among women has reached an alarming stage compared to 20 years ago. It was found that single nucleotide polymorphisms (SNPs) play an important role in the development of breast cancer. SNPs may suppress or activate the functional genes, which then leads to an increased survival of cell...

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Main Authors: Yow, Weng Kit, Mahmud, Rozi, Ling, King Hwa, Thilakavathy, Karuppiah
Format: Article
Language:English
Published: INNO Publisher 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61027/1/Breast%20cancer%20associated%20mutations%20reported%20among%20Malaysian%20Malay%2C%20Chinese%20and%20Indian%20patients.pdf
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spelling oai:psasir.upm.edu.my:61027 http://psasir.upm.edu.my/id/eprint/61027/ Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients Yow, Weng Kit Mahmud, Rozi Ling, King Hwa Thilakavathy, Karuppiah Breast cancer among women has reached an alarming stage compared to 20 years ago. It was found that single nucleotide polymorphisms (SNPs) play an important role in the development of breast cancer. SNPs may suppress or activate the functional genes, which then leads to an increased survival of cells due to the suppression of tumour suppressor genes or increased activity in detrimental proteins, resulting in cancers. Recently, breast cancer research is given significant attention due to the increasing number of breast cancer patients in Malaysia each year. However, breast cancer researches in Malaysia are mainly focused on well known breast cancer genes such as BRCA1 and BRCA2. There is less emphasis on the other breast cancer contributing genes. This paper was aimed to review the research findings on mutations associated with breast cancer in Malaysian Malay, Malaysian Chinese and Malaysian Indian as it has never been cumulatively reported and to ascertain the common mutations found in these three major Malaysia ethnicity. INNO Publisher 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61027/1/Breast%20cancer%20associated%20mutations%20reported%20among%20Malaysian%20Malay%2C%20Chinese%20and%20Indian%20patients.pdf Yow, Weng Kit and Mahmud, Rozi and Ling, King Hwa and Thilakavathy, Karuppiah (2017) Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients. Progress in Bioscience and Bioengineering, 1 (2). 1- 11. 10.29269/pbb2017.v1i2.19
institution UPM IR
collection UPM IR
language English
description Breast cancer among women has reached an alarming stage compared to 20 years ago. It was found that single nucleotide polymorphisms (SNPs) play an important role in the development of breast cancer. SNPs may suppress or activate the functional genes, which then leads to an increased survival of cells due to the suppression of tumour suppressor genes or increased activity in detrimental proteins, resulting in cancers. Recently, breast cancer research is given significant attention due to the increasing number of breast cancer patients in Malaysia each year. However, breast cancer researches in Malaysia are mainly focused on well known breast cancer genes such as BRCA1 and BRCA2. There is less emphasis on the other breast cancer contributing genes. This paper was aimed to review the research findings on mutations associated with breast cancer in Malaysian Malay, Malaysian Chinese and Malaysian Indian as it has never been cumulatively reported and to ascertain the common mutations found in these three major Malaysia ethnicity.
format Article
author Yow, Weng Kit
Mahmud, Rozi
Ling, King Hwa
Thilakavathy, Karuppiah
spellingShingle Yow, Weng Kit
Mahmud, Rozi
Ling, King Hwa
Thilakavathy, Karuppiah
Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
author_facet Yow, Weng Kit
Mahmud, Rozi
Ling, King Hwa
Thilakavathy, Karuppiah
author_sort Yow, Weng Kit
title Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
title_short Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
title_full Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
title_fullStr Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
title_full_unstemmed Breast cancer associated mutations reported among Malaysian Malay, Chinese and Indian patients
title_sort breast cancer associated mutations reported among malaysian malay, chinese and indian patients
publisher INNO Publisher
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/61027/1/Breast%20cancer%20associated%20mutations%20reported%20among%20Malaysian%20Malay%2C%20Chinese%20and%20Indian%20patients.pdf
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score 12.833586