TY  - JOUR
T1  - Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine
A1  - Nor, Siti Mariam Mohd
LA  - English
PB  - Asian Publication Corporation
YR  - 2017
UL  - http://discoverylib.upm.edu.my/discovery/Record/oai:psasir.upm.edu.my:63365
AB  - Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinimbine. N-Benzylgirinimbine, N-butylgirinimbine and N-isopentylgirinimbine were obtained from alkylation reaction, whereas, N-butyrylgirinimbine and N-methylbutyrylgirinimbine were obtained from acylation reaction. The structures of synthesized girinimbine derivatives were confirmed by spectroscopic techniques.
ER  -