Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4

Bacteria and their metabolites are shown to be a potential therapeutic agent for cancer treatment. Much attention has been directed to Lactic acid bacteria (LAB) which exhibits several killing mechanisms via invasion and colonization of solid tumors. Discovery of the characteristics of postbiotic me...

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Main Authors: Muhamad Zakuan, Noraina, Foo, Hooi Ling, Saiful Yazan, Latifah
Format: Article
Jezik:English
Izdano: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2019
Online dostop:http://psasir.upm.edu.my/id/eprint/70056/1/2019070210033012_MJMHS_SP2_2019.pdf
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id oai:psasir.upm.edu.my:70056
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spelling oai:psasir.upm.edu.my:70056 http://psasir.upm.edu.my/id/eprint/70056/ Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4 Muhamad Zakuan, Noraina Foo, Hooi Ling Saiful Yazan, Latifah Bacteria and their metabolites are shown to be a potential therapeutic agent for cancer treatment. Much attention has been directed to Lactic acid bacteria (LAB) which exhibits several killing mechanisms via invasion and colonization of solid tumors. Discovery of the characteristics of postbiotic metabolites that exert the same probiotic effects has attracted immense attention towards anti-cancer effect. It is known that LAB improves health and composition of microbiota in the gut. Supplementation of LAB is proven to enhance the host immunity and modulation of the immune system to fight diseases including cancers. Lactobacillus plantarum I-UL4 is the LAB species isolated from Malaysian fermented food, Tapai Ubi which capable of producing bioactive metabolic products. In this review, the properties of UL4-PPM will be discussed including anti-microbial, anti-cancer and immunomodulatory effects. Overall, it would be beneficial to discover the potential effects of UL4-PPM to possibly serve as an alternative treatment for cancer. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/70056/1/2019070210033012_MJMHS_SP2_2019.pdf Muhamad Zakuan, Noraina and Foo, Hooi Ling and Saiful Yazan, Latifah (2019) Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4. Malaysian Journal of Medicine and Health Sciences, 15 (SP2). pp. 81-84. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2019070210033012_MJMHS_SP2_2019.pdf
institution UPM IR
collection UPM IR
language English
description Bacteria and their metabolites are shown to be a potential therapeutic agent for cancer treatment. Much attention has been directed to Lactic acid bacteria (LAB) which exhibits several killing mechanisms via invasion and colonization of solid tumors. Discovery of the characteristics of postbiotic metabolites that exert the same probiotic effects has attracted immense attention towards anti-cancer effect. It is known that LAB improves health and composition of microbiota in the gut. Supplementation of LAB is proven to enhance the host immunity and modulation of the immune system to fight diseases including cancers. Lactobacillus plantarum I-UL4 is the LAB species isolated from Malaysian fermented food, Tapai Ubi which capable of producing bioactive metabolic products. In this review, the properties of UL4-PPM will be discussed including anti-microbial, anti-cancer and immunomodulatory effects. Overall, it would be beneficial to discover the potential effects of UL4-PPM to possibly serve as an alternative treatment for cancer.
format Article
author Muhamad Zakuan, Noraina
Foo, Hooi Ling
Saiful Yazan, Latifah
spellingShingle Muhamad Zakuan, Noraina
Foo, Hooi Ling
Saiful Yazan, Latifah
Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
author_facet Muhamad Zakuan, Noraina
Foo, Hooi Ling
Saiful Yazan, Latifah
author_sort Muhamad Zakuan, Noraina
title Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
title_short Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
title_full Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
title_fullStr Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
title_full_unstemmed Anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by Lactobacillus plantarum I-UL4
title_sort anti-microbial, anti-cancer and immunomodulatory properties of proteinaceous postbiotic metabolite produced by lactobacillus plantarum i-ul4
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/70056/1/2019070210033012_MJMHS_SP2_2019.pdf
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score 13.4562235