Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determ...
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| Main Authors: | , , , , , |
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| 格式: | Article |
| 语言: | English |
| 出版: |
Publications International
2018
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| 在线阅读: | http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf |
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| 总结: | Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent. |
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