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Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)

Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determ...

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Egile Nagusiak: Mat Amin, Nakisah, Hamdin, Muhammad Shafiq, Azarnudin, Muhd Amir Taufiq, Asari, Asnuzilawati, Abdul Rashid, Fatin Nur Ain, Mohd Nor, Siti Mariam
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Publications International 2018
Sarrera elektronikoa:http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf
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spelling oai:psasir.upm.edu.my:72164 http://psasir.upm.edu.my/id/eprint/72164/ Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) Mat Amin, Nakisah Hamdin, Muhammad Shafiq Azarnudin, Muhd Amir Taufiq Asari, Asnuzilawati Abdul Rashid, Fatin Nur Ain Mohd Nor, Siti Mariam Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent. Publications International 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf Mat Amin, Nakisah and Hamdin, Muhammad Shafiq and Azarnudin, Muhd Amir Taufiq and Asari, Asnuzilawati and Abdul Rashid, Fatin Nur Ain and Mohd Nor, Siti Mariam (2018) Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate). Science International, 30 (2). 309 - 301. ISSN 1013-5316 http://www.sci-int.com/Search?catid=98
institution UPM IR
collection UPM IR
language English
description Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent.
format Article
author Mat Amin, Nakisah
Hamdin, Muhammad Shafiq
Azarnudin, Muhd Amir Taufiq
Asari, Asnuzilawati
Abdul Rashid, Fatin Nur Ain
Mohd Nor, Siti Mariam
spellingShingle Mat Amin, Nakisah
Hamdin, Muhammad Shafiq
Azarnudin, Muhd Amir Taufiq
Asari, Asnuzilawati
Abdul Rashid, Fatin Nur Ain
Mohd Nor, Siti Mariam
Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
author_facet Mat Amin, Nakisah
Hamdin, Muhammad Shafiq
Azarnudin, Muhd Amir Taufiq
Asari, Asnuzilawati
Abdul Rashid, Fatin Nur Ain
Mohd Nor, Siti Mariam
author_sort Mat Amin, Nakisah
title Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
title_short Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
title_full Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
title_fullStr Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
title_full_unstemmed Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
title_sort cytotoxicity effect of aaptamine and its derivatives on acanthamoeba castellanii (imr isolate)
publisher Publications International
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf
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score 13.4562235

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