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Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia

The humoral immune responses against 46 different staphylococcal antigens in 27 bacteremia patients infected by clonally related methicillin-resistant Staphylococcus aureus (MRSA) strains of a single sequence type (ST) 239 were investigated. A group of non-infected patients (n = 31) hospitalized for...

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Main Authors: H. Ghasemzadeh, Moghaddam, Hamat, R. A., Neela, V. K., WJB van, Wamel, A. van, Belkum, Tavakol, M.
Format: Article
Language:English
Published: Springer 2018
Online Access:http://psasir.upm.edu.my/id/eprint/74525/1/Humoral%20immune.pdf
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spelling oai:psasir.upm.edu.my:74525 http://psasir.upm.edu.my/id/eprint/74525/ Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia H. Ghasemzadeh, Moghaddam Hamat, R. A. Neela, V. K. WJB van, Wamel A. van, Belkum Tavakol, M. The humoral immune responses against 46 different staphylococcal antigens in 27 bacteremia patients infected by clonally related methicillin-resistant Staphylococcus aureus (MRSA) strains of a single sequence type (ST) 239 were investigated. A group of non-infected patients (n = 31) hospitalized for different reasons served as controls. All strains were confirmed as ST 239 by S. aureus and mecA-specific PCR, spa, and multi-locus sequence typing (MLST). In each bacteremia patient, a unique pattern of S. aureus antigen-specific immune responses after infection was observed. Antibody levels among bacteremia patients were significantly higher than controls for HlgB (P = 0.001), LukD (P = 0.009), LukF (P = 0.0001), SEA (P = 0.0001), SEB (P = 0.011), SEC (P = 0.010), SEQ (P = 0.049), IsaA (P = 0.043), IsdA (P = 0.038), IsdH (P = 0.01), SdrD (P = 0.001), SdrE (P = 0.046), EsxA (P = 0.0001), and SA0104 (P = 0.0001). On the other hand, the antibody levels were significantly higher among controls for SSL3 (P = 0.009), SSL9 (P = 0.002), and SSL10 (P = 0.007) when the IgG level on the day of infection was compared with that measured on the day of admission. Diversity was observed in the immune response against the antigens. However, a set of antigens (IsaA, IsdA, IsdH, SdrD, and HlgB) triggered a similar type of immune response in different individuals. We suggest that these antigens could be considered when developing a multi-component (passive) vaccine. SEA and/or its specific antibodies seem to play a critical role during ST239 MRSA bacteremia and SEA-targeted therapy may be a strategy to be considered. Springer 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74525/1/Humoral%20immune.pdf H. Ghasemzadeh, Moghaddam and Hamat, R. A. and Neela, V. K. and WJB van, Wamel and A. van, Belkum and Tavakol, M. (2018) Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia. European Journal of Clinical Microbiology and Infectious Disease, 37 (2). 255 - 263. ISSN 0934-9723, ESSN: 1435-4373 10.1007/s10096-017-3124-3
institution UPM IR
collection UPM IR
language English
description The humoral immune responses against 46 different staphylococcal antigens in 27 bacteremia patients infected by clonally related methicillin-resistant Staphylococcus aureus (MRSA) strains of a single sequence type (ST) 239 were investigated. A group of non-infected patients (n = 31) hospitalized for different reasons served as controls. All strains were confirmed as ST 239 by S. aureus and mecA-specific PCR, spa, and multi-locus sequence typing (MLST). In each bacteremia patient, a unique pattern of S. aureus antigen-specific immune responses after infection was observed. Antibody levels among bacteremia patients were significantly higher than controls for HlgB (P = 0.001), LukD (P = 0.009), LukF (P = 0.0001), SEA (P = 0.0001), SEB (P = 0.011), SEC (P = 0.010), SEQ (P = 0.049), IsaA (P = 0.043), IsdA (P = 0.038), IsdH (P = 0.01), SdrD (P = 0.001), SdrE (P = 0.046), EsxA (P = 0.0001), and SA0104 (P = 0.0001). On the other hand, the antibody levels were significantly higher among controls for SSL3 (P = 0.009), SSL9 (P = 0.002), and SSL10 (P = 0.007) when the IgG level on the day of infection was compared with that measured on the day of admission. Diversity was observed in the immune response against the antigens. However, a set of antigens (IsaA, IsdA, IsdH, SdrD, and HlgB) triggered a similar type of immune response in different individuals. We suggest that these antigens could be considered when developing a multi-component (passive) vaccine. SEA and/or its specific antibodies seem to play a critical role during ST239 MRSA bacteremia and SEA-targeted therapy may be a strategy to be considered.
format Article
author H. Ghasemzadeh, Moghaddam
Hamat, R. A.
Neela, V. K.
WJB van, Wamel
A. van, Belkum
Tavakol, M.
spellingShingle H. Ghasemzadeh, Moghaddam
Hamat, R. A.
Neela, V. K.
WJB van, Wamel
A. van, Belkum
Tavakol, M.
Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
author_facet H. Ghasemzadeh, Moghaddam
Hamat, R. A.
Neela, V. K.
WJB van, Wamel
A. van, Belkum
Tavakol, M.
author_sort H. Ghasemzadeh, Moghaddam
title Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
title_short Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
title_full Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
title_fullStr Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
title_full_unstemmed Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
title_sort humoral immune consequences of staphylococcus aureus st239-associated bacteremia
publisher Springer
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/74525/1/Humoral%20immune.pdf
_version_ 1819299175792115712
score 13.4562235

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