Imagem da capa

Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection

Lambs with the Major Histocompatibility Complex DRB1*1101 allele have been shown to produce fewer nematode eggs following natural and deliberate infection. These sheep also possess fewer adult Teladorsagia circumcincta than sheep with alternative alleles at the DRB1 locus. However, it is unclear if...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Stear, Abigail, Ali, Alsagher Omran A., Brujeni, Gholamreza Nikbakht, Buitkamp, Johannes, Lysoniewska, Katarzyna Donskow, Clarke, Karen Fairlie, Groth, David, Md Isa, Nur Mahiza, Stear, Michael J.
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2019
Acesso em linha:http://psasir.upm.edu.my/id/eprint/80137/1/Identification%20of%20the%20amino%20acids%20in%20the%20major%20histocompatibility%20complex%20class%20II%20region%20of%20scottish%20blackface%20sheep%20that%20are%20associated%20with%20resistance%20to%20nematode%20infection.pdf
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id oai:psasir.upm.edu.my:80137
record_format eprints
spelling oai:psasir.upm.edu.my:80137 http://psasir.upm.edu.my/id/eprint/80137/ Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection Stear, Abigail Ali, Alsagher Omran A. Brujeni, Gholamreza Nikbakht Buitkamp, Johannes Lysoniewska, Katarzyna Donskow Clarke, Karen Fairlie Groth, David Md Isa, Nur Mahiza Stear, Michael J. Lambs with the Major Histocompatibility Complex DRB1*1101 allele have been shown to produce fewer nematode eggs following natural and deliberate infection. These sheep also possess fewer adult Teladorsagia circumcincta than sheep with alternative alleles at the DRB1 locus. However, it is unclear if this allele is responsible for the reduced egg counts or merely acts as a marker for a linked gene. This study defined the MHC haplotypes in a population of naturally infected Scottish Blackface sheep by PCR amplification and sequencing, and examined the associations between MHC haplotypes and faecal egg counts by generalised linear mixed modelling. The DRB1*1101 allele occurred predominately on one haplotype and a comparison of haplotypes indicated that the causal mutation or mutations occurred in or around this locus. Additional comparisons with another resistant haplotype indicated that mutations in or around the DQB2*GU191460 allele were also responsible for resistance to nematode infections. Further analyses identified six amino acid substitutions in the antigen binding site of DRB1*1101 that were significantly associated with reductions in the numbers of adult T. circumcincta. Elsevier 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80137/1/Identification%20of%20the%20amino%20acids%20in%20the%20major%20histocompatibility%20complex%20class%20II%20region%20of%20scottish%20blackface%20sheep%20that%20are%20associated%20with%20resistance%20to%20nematode%20infection.pdf Stear, Abigail and Ali, Alsagher Omran A. and Brujeni, Gholamreza Nikbakht and Buitkamp, Johannes and Lysoniewska, Katarzyna Donskow and Clarke, Karen Fairlie and Groth, David and Md Isa, Nur Mahiza and Stear, Michael J. (2019) Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection. International Journal for Parasitology, 49. pp. 797-804. ISSN 0020-7519; ESSN: 1879-0135 https://reader.elsevier.com/reader/sd/pii/S0020751919301699?token=DCB944858CBABE437D2116E366E9B87187FEC10BA482EC40F6B8D0E62C1D2118234E6CEB0652F2DBCA88A7A966A92631 10.1016/j.ijpara.2019.05.003
institution UPM IR
collection UPM IR
language English
description Lambs with the Major Histocompatibility Complex DRB1*1101 allele have been shown to produce fewer nematode eggs following natural and deliberate infection. These sheep also possess fewer adult Teladorsagia circumcincta than sheep with alternative alleles at the DRB1 locus. However, it is unclear if this allele is responsible for the reduced egg counts or merely acts as a marker for a linked gene. This study defined the MHC haplotypes in a population of naturally infected Scottish Blackface sheep by PCR amplification and sequencing, and examined the associations between MHC haplotypes and faecal egg counts by generalised linear mixed modelling. The DRB1*1101 allele occurred predominately on one haplotype and a comparison of haplotypes indicated that the causal mutation or mutations occurred in or around this locus. Additional comparisons with another resistant haplotype indicated that mutations in or around the DQB2*GU191460 allele were also responsible for resistance to nematode infections. Further analyses identified six amino acid substitutions in the antigen binding site of DRB1*1101 that were significantly associated with reductions in the numbers of adult T. circumcincta.
format Article
author Stear, Abigail
Ali, Alsagher Omran A.
Brujeni, Gholamreza Nikbakht
Buitkamp, Johannes
Lysoniewska, Katarzyna Donskow
Clarke, Karen Fairlie
Groth, David
Md Isa, Nur Mahiza
Stear, Michael J.
spellingShingle Stear, Abigail
Ali, Alsagher Omran A.
Brujeni, Gholamreza Nikbakht
Buitkamp, Johannes
Lysoniewska, Katarzyna Donskow
Clarke, Karen Fairlie
Groth, David
Md Isa, Nur Mahiza
Stear, Michael J.
Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
author_facet Stear, Abigail
Ali, Alsagher Omran A.
Brujeni, Gholamreza Nikbakht
Buitkamp, Johannes
Lysoniewska, Katarzyna Donskow
Clarke, Karen Fairlie
Groth, David
Md Isa, Nur Mahiza
Stear, Michael J.
author_sort Stear, Abigail
title Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
title_short Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
title_full Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
title_fullStr Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
title_full_unstemmed Identification of the amino acids in the major histocompatibility complex class II region of scottish blackface sheep that are associated with resistance to nematode infection
title_sort identification of the amino acids in the major histocompatibility complex class ii region of scottish blackface sheep that are associated with resistance to nematode infection
publisher Elsevier
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/80137/1/Identification%20of%20the%20amino%20acids%20in%20the%20major%20histocompatibility%20complex%20class%20II%20region%20of%20scottish%20blackface%20sheep%20that%20are%20associated%20with%20resistance%20to%20nematode%20infection.pdf
_version_ 1819299649080524800
score 13.4562235

Registos relacionados