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Potential miRNAs for miRNA-based therapeutics in breast cancer

MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation...

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Main Authors: Wong, Jun Sheng, Cheah, Yoke Kqueen
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020
Online Access:http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf
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spelling oai:psasir.upm.edu.my:87221 http://psasir.upm.edu.my/id/eprint/87221/ Potential miRNAs for miRNA-based therapeutics in breast cancer Wong, Jun Sheng Cheah, Yoke Kqueen MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf Wong, Jun Sheng and Cheah, Yoke Kqueen (2020) Potential miRNAs for miRNA-based therapeutics in breast cancer. Non-coding RNA, 6 (3). art. no. 29. pp. 1-39. ISSN 2311-553X https://www.mdpi.com/2311-553X/6/3/29 10.3390/ncrna6030029
institution UPM IR
collection UPM IR
language English
description MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications.
format Article
author Wong, Jun Sheng
Cheah, Yoke Kqueen
spellingShingle Wong, Jun Sheng
Cheah, Yoke Kqueen
Potential miRNAs for miRNA-based therapeutics in breast cancer
author_facet Wong, Jun Sheng
Cheah, Yoke Kqueen
author_sort Wong, Jun Sheng
title Potential miRNAs for miRNA-based therapeutics in breast cancer
title_short Potential miRNAs for miRNA-based therapeutics in breast cancer
title_full Potential miRNAs for miRNA-based therapeutics in breast cancer
title_fullStr Potential miRNAs for miRNA-based therapeutics in breast cancer
title_full_unstemmed Potential miRNAs for miRNA-based therapeutics in breast cancer
title_sort potential mirnas for mirna-based therapeutics in breast cancer
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/87221/1/Potential%20miRNAs%20for%20miRNA.pdf
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score 12.918464

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