Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach
Aristolochic acid I (AAI) is a well-known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA-reactive aristolactam-nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI-DNA adduct formation in the kidney of rat, mouse and human...
Na minha lista:
| Principais autores: | , , , , , |
|---|---|
| Formato: | Atigo |
| Idioma: | English |
| Publicado em: |
John Wiley & Sons
2020
|
| Acesso em linha: | http://psasir.upm.edu.my/id/eprint/88350/1/ABSTRACT.pdf |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
Seja o primeiro a deixar um comentário!